Thứ Ba, 20 tháng 1, 2015

Key Chiral Auxiliary Applications, Second Edition

Key Chiral Auxiliary Applications, Second Edition



Asymmeric synthesis is extremely important for many applications, especially in industrial chemistry. When a reaction forms a chiral molecule, the two possible enantiomeric products can have very different properties; one may be a beneficial drug and the other may be toxic. It is therefore very important to be able to make a pure enantiomer. For example the drug thalidimide was used in the 1950s by women to reduce the discomfort of pregnancy; unknown at the time, it was a mixture of enantiomers of the same molecule. One enantiomer was therapeutic, the other was later found to be toxic, but had already resulted in many cases of birth defects, particularly in Japan and Europe. Chiral molecules are also involved in dyes and pigments, fragrances, flavors and many other commercial applications. One alternative to using a chiral auxiliary to make a pure enantiomer is to make both enantiomers and then purify out the desired one but this method is wasteful in terms of chemicals used, expensive and time consuming.




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