An Introduction to Toxicology

An Introduction to Toxicology

This book provides a readable introduction to modern toxicology with a particular focus on the mechanisms underlying the induction of toxicity by foreign substances. Since bioactivation is central to many toxic syndromes, special interest is devoted to chemicals that undergo conversion to toxic metabolites that induce toxic effects as diverse as cancer, birth defects and organ injury. The molecular consequences accompanying damage to cellular DNA and proteins is explored together with the relevance of toxicological paradigms to human diseases caused by alcohol and tobacco. The discipline of toxicology has developed rapidly since the thalidomide disaster in the 1960s as scientists worldwide seek to understand the adverse health effects of human medicines, environmental pollutants, consumer chemicals and industrial reagents. An Introduction to Toxicology is intended to supplement the recommended reading list of undergraduate and graduate programs in toxicology and pharmacology as an enjoyable, accessible primer with illustrations that unpack the concepts being discussed in the text.

An Introduction to Toxicology

71st Conference on Glass Problems

71st Conference on Glass Problems

This issue contains a collection of papers presented at the 71st Conference on Glass Problems, October 19-20, 2010 at The Ohio State University, Columbus, Ohio. Topics include glass melting; glass science, defects; safety; refractories; recycling; controls; and raw materials.

71st Conference on Glass Problems

Inborn Metabolic Diseases - Fifth Edition

Inborn Metabolic Diseases - Fifth Edition

This henceforth classical textbook has become indispensable for those in the front line dealing with metabolic disorders. As with previous editions the book is aimed at all those involved with this specialty including pediatricians, biochemists, dieticians, neurologists, internists, geneticists, psychologists, nurses, and social workers. This 4th edition has been thoroughly updated and revised and John Walter has joined the three other editors. One new chapter on Neonatal screening by tandem MS/MS has been added and several new groups of disorders have been included; for example defects involving the pentose phosphate pathway (polyols metabolism) and disorders of glucose transport. The first chapter presents the clinical approach to inherited metabolic disease using many algorithms and tables and has been entirely revised and extended to include adult metabolic medicine. It now incorporates many new findings particularly in neuroradiology and neurophysiology and emphasises those disorders for which treatment is available. This accessible and practical book can be used either by going directly to the relevant chapter when the diagnosis is already suspected or by referring to Chapter 1 if it is unknown. Despite the numerous updates the book has been maintained at a reasonable size and is published as a single volume of approximately 550 pages divided into 43 Chapters.

Inborn Metabolic Diseases - Fifth Edition

Key Chiral Auxiliary Applications, Second Edition

Key Chiral Auxiliary Applications, Second Edition

Asymmeric synthesis is extremely important for many applications, especially in industrial chemistry. When a reaction forms a chiral molecule, the two possible enantiomeric products can have very different properties; one may be a beneficial drug and the other may be toxic. It is therefore very important to be able to make a pure enantiomer. For example the drug thalidimide was used in the 1950s by women to reduce the discomfort of pregnancy; unknown at the time, it was a mixture of enantiomers of the same molecule. One enantiomer was therapeutic, the other was later found to be toxic, but had already resulted in many cases of birth defects, particularly in Japan and Europe. Chiral molecules are also involved in dyes and pigments, fragrances, flavors and many other commercial applications. One alternative to using a chiral auxiliary to make a pure enantiomer is to make both enantiomers and then purify out the desired one but this method is wasteful in terms of chemicals used, expensive and time consuming.

Key Chiral Auxiliary Applications, Second Edition

Quasicrystals

Quasicrystals

The book provides an introduction to all aspects of the physics of quasicrystals. The chapters, each written by an expert in this field, cover quasiperiodic tilings and the modeling of the atomic structure of quasicrystals. The electronic density of states and the calculation of the electronic structure play a key role in this introduction, as does an extensive discussion of the atomic dynamics. The study of defects in quasicrystals by high resolution electron microscopy and the computer simulations of defects and fracture in decorated tilings are important subjects for the application of these aperiodic crystals.

Quasicrystals

Advances in Silicon Carbide Processing and Applications

Advances in Silicon Carbide Processing and Applications

‘Advances In Silicon Carbide Processing and Applications provides detailed coverage of the latest advances in SiC (silicon carbide) technology from the leading experts in the field. The book serves as the professional’s single source for in-depth information on both SiC device fabrication and system-level applications. This comprehensive reference begins with an examination of how SiC is grown and how defects in SiC growth can affect working devices.’ ‘Key issues in selective doping of SiC via ion implantation are covered with a special focus on implant conditions and electrical activation of implants. SiC applications discussed include chemical sensors, motor-control components, high-temperature gas sensors, and high-temperature electronics. By cutting through the arcane data and jargon surrounding the hype on SiC, this book gives an assessment of today’s SiC technology and explains how SiC can be adopted in developing tomorrow’s applications.’–BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved

Advances in Silicon Carbide Processing and Applications