Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. Volume 40, GeneTherapy, features important new research on gene transfers and therapy in the herpes simplex virus, anti-tumor immunity, steroid receptors, cystic fibroses, and more.
How are medicines transported intact through the body to their specific target sites without triggering side effects? The answer is ‘Drug Targeting’.
This book, which combines the features of an atlas and a textbook, presents findings in forensic histology, immunohistochemistry, and cytology based on microscopic investigations using different stainings and different antibodies. The principal aim is to provide practitioners with detailed information and guidance on how microscopy can help to clarify the cause of sudden and unexpected death. Many of the topics will be of interest not only to forensic pathologists but also to general pathologists, whether practitioners or researchers. Examples include the pathology of drug abuse, wound age determination, adverse drug reactions, histopathology of the sudden infant death syndrome, and age determination of myocardial infarction. Both typical and unusual findings are demonstrated with the aid of numerous high-quality color illustrations, and other key literature in forensic histology and immunohistochemistry is highlighted for each topic.
As part of the Reliable Lab Solutions series, this volume offers an abridged and comprehensive update of selected chapters that first appeared in the three-volume stem cell series published in Methods in Enzymology. Currently, stem cells are of great interest to scientists and clinicians due to their unique ability to differentiate into various tissues of the body, making them a promising source of cells for regenerative medicine and drug discovery as well as an excellent model of vertebrate development. ‘Essential Stem Cell Methods’features a detailed set ofprotocolswritten by experts in the field and hand-selected by the editors to helpresearchers drive advances in this fast-moving field. The result is a clear set of step-by-stepmethods which steer the reader through the challenges of stem cell isolation and differentiation and provide a handy guide for researchers in the field.
Pharmaceutics: Basic Principles and Application to Pharmacy Practice is a valuable textbook covering the basic science as well as the role and application of pharmaceutics within pharmacy practice. Based on curricular guidelines mandated by the American Council for Pharmacy Education (ACPE), this book incorporates laboratory skills by identifying portions of each principle that can be used in a clinical setting. In this way, instructors are able to demonstrate their adherence to ACPE standards and objectives simply by using this book. A companion website for students and instructors further enhance the didactic content for students by including practice questions and answers and videos that feature difficult processes and procedures. Essential resources for instructors are also available and include chapter PowerPoint slides and full-color images. Full of practical examples and case studies for experiential learning, Pharmaceutics enables students to gain the scientific foundation to understand drug physicochemical properties, practical aspects of dosage forms and drug delivery systems, and the biological applications of drug administration.
This Brief explores emerging trends in drug use and distribution. This timely Brief examines recent examples of emerging drugs including salvia (from the plant Salvia divinorum), bath salts (and other synthetic stimulants) and so-called research chemicals (primarily substituted phenethylamines, synthetic cousins of ecstasy), which have tended to receive brief levels of high intensity media coverage that may or may not reflect an actual increase in their usage. Over the past decade in particular, new substances being used recreationally seem to come out of obscurity and gain rapid popularity, particularly spurred on by discussion and distribution over the internet. While changing trends in the drug market have always presented a challenge for law enforcement and public health officials, online forums, media coverage and other recent trends discussed in this Brief allow them to gain popularity more quickly and change more frequently. These rapid shifts allow less time for researchers to understand the potential health consequences of these substances and for law enforcement to stay abreast of abuses of legal substances. This work includes: 1) review of relevant research and literature, 2) review the Internet sources in which many deem important in influencing the emerging drug market, 3) discussion of national and international trends in use, abuse and distribution of these substances and 4) examination of current drug policy and recommendations for the future. This brief will be useful for criminology and criminal justice, sociology and public health. It will also be useful for those that deal with youth and the problems that may develop during adolescence and early adulthood.
New strategies and techniques for today’s fast-paced discovery process
Surface chemistry plays an important role in everyday life, as the basis for many phenomena as well as technological applications. Common examples range from soap bubbles, foam, and raindrops to cosmetics, paint, adhesives, and pharmaceuticals. Additional areas that rely on surface chemistry include modern nanotechnology, medical diagnostics, and drug delivery. There is extensive literature on this subject, but most chemistry books only devote one or two chapters to it. Surface Chemistry Essentials fills a need for a reference that brings together the fundamental aspects of surface chemistry with up-to-date references and data from real-world examples.
When you play with fire, everyone gets burned . . . Joe Weeks is new to the Grange Estate. Tolerant, doesnt mind a bit of weed, doesnt try to pull other mens women. Live and let live is his motto . . . Eddie Quinn is the hardest man on the estate. Everyone knows that its a bad idea to cross him, or his pit bull. But everyone also knows he’s honest, as drug dealers go. Joes pleased when Eddie offers him a job. But then he meets Katya. A prostitute. A slave. And desperate to escape from Eddie.
Asymmeric synthesis is extremely important for many applications, especially in industrial chemistry. When a reaction forms a chiral molecule, the two possible enantiomeric products can have very different properties; one may be a beneficial drug and the other may be toxic. It is therefore very important to be able to make a pure enantiomer. For example the drug thalidimide was used in the 1950s by women to reduce the discomfort of pregnancy; unknown at the time, it was a mixture of enantiomers of the same molecule. One enantiomer was therapeutic, the other was later found to be toxic, but had already resulted in many cases of birth defects, particularly in Japan and Europe. Chiral molecules are also involved in dyes and pigments, fragrances, flavors and many other commercial applications. One alternative to using a chiral auxiliary to make a pure enantiomer is to make both enantiomers and then purify out the desired one but this method is wasteful in terms of chemicals used, expensive and time consuming.
This book was first published in 2009. Set in Hyderabad in the mid-nineteenth and early twentieth centuries, this book, a study of the cultural world of the Muslim soldiers of colonial India, focuses on the soldiers’ relationships with the faqir holy men who protected them and the British officers they served. Drawing on Urdu as well as European sources, the book uses the biographies of Muslim holy men and their military followers to recreate the extraordinary encounter between a barracks culture of miracle stories, carnivals, drug-use and madness with a colonial culture of mutiny memoirs, Evangelicalism, magistrates and the asylum. It explores the ways in which the colonial army helped promote this sepoy religion while at the same time attempting to control and suppress certain aspects of it. The book brings to light the existence of a distinct ‘barracks Islam’ and shows its importance to the cultural no less than the military history of colonial India.
The book gives an update on different aspects of drug addiction and AIDS. The first chapters deal with the biological aspects of drug addiction, from cloning of brain opioid receptors to the mechanisms of dependence development. The second part confirms the validity of methadone maintenance treatments in controlling heroin addiction, and shows the spreading of methadone use in different European countries. Methadone maintenance also appears as the most valid strategy in HIV epidemics prevention. The most recent acquisition on AIDS diagnostic criteria and treatment protocols are discussed. The debate on these topics remains unresolved but the authoritative opinions and the significant data reported will help in attenuating emotionality, and will favor a progressively more pragmatic approach.
James Balch and Mark Stengler, coauthors of the hugely successful Prescription for Natural Cures, and Robin Young Balch have teamed up to create the most comprehensive and up-to-date book available on natural alternatives to prescription medications. The book provides natural, safe, and effective ways to treat a wide range of common ailments, including ADHD, allergies, diabetes, depression, erectile dysfunction, eczema, heart disease, headaches, and PMS. Youll read in-depth information, not found in any other popular book, about the pros and cons of prescription and over-the-counter drugs compared with natural treatment alternatives ranging from diet and lifestyle changes to supplements and herbal medicines.
This book summarises the recent development in acupuncture research and in particular, the neurobiology of acupuncture. It provides a focus but a diverse range of subjects covering many body systems. The first a few chapters discuss the basic principles of acupuncture, then its modulatory effects on nervous system such as induction of neurotrophin and neurogenesis in the brain. Late chapters explore the clinical effects and potential mechanisms of acupuncture on different conditions ranging from neurological diseases such as Parkinsons, Alzheimers, and stroke, to psychiatric illnesses, insomnia, hypertension, gastrointestinal diseases and drug addiction. We believe this will promote the understanding acupuncture treatment and enhance acupuncture research in the future.
This handy reference details state-of-the-art preparation of molecular assemblies of biotechnologically relevant biomimetic systems (artificial proteins, peptides, molecular motors, photosensitive systems) with an emphasis on biomimetic membranes, capsules, and interfaces. Medical applications such as drug release, gene therapy, and tissue engineering as well as biosensing, biocatalysis, and energy storage are highlighted.
Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. Chapter authors from leading pharmaceutical companies as well as from Harvard University discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results.
This book offers an overview of the complex interplay between hormonal activation and individual and environmental influences on health and disease in women. The book provides useful information and background material important for treating problems related to the reproductive cycle, eating disorders, drug treatment of women, and clinical and treatment issues in coronary artery disease and breast cancer. This is a medically-oriented book written firstly for the practicing physician in primary care, psychiatry, internal medicine and gynecology/obstetrics. This book takes a much broader view than others on the market by combining consideration of both psychological and physical disorders affecting women and by discussing treatment issues.
