Engineering in Translational Medicine

Engineering in Translational Medicine

This book covers a broad area of engineering research in translational medicine. Leaders in academic institutions around the world contributed focused chapters on a broad array of topics such as: cell and tissue engineering (6 chapters), genetic and protein engineering (10 chapters), nanoengineering (10 chapters), biomedical instrumentation (4 chapters), and theranostics and other novel approaches (4 chapters). Each chapter is a stand-alone review that summarizes the state-of-the-art of the specific research area.

Engineering in Translational Medicine

10 Laps around Silverlight

10 Laps around Silverlight

0

10 Laps around Silverlight

Blood Country

Blood Country

This first in a series launch introduces Claire Watkins, a deputy sheriff for the Pepin County Police Department. Claire, a former Minneapolis police detective, and her 10-year-old daughter Meg fled the Twin Cities after her husband, Steve, also a cop, was killed.

Blood Country

Fractals and Disordered Systems - Second Edition

Fractals and Disordered Systems - Second Edition

Fractals and disordered systems have recently become the focus of intense interest in research. This book discusses in great detail the effects of disorder on mesoscopic scales (fractures, aggregates, colloids, surfaces and interfaces, glasses and polymers) and presents tools to describe them in mathematical language. A substantial part is devoted to the development of scaling theories based on fractal concepts. In 10 chapters written by leading experts in the field, the reader is introduced to basic concepts and techniques in disordered systems and is led to the forefront of current research. In each chapter, the connection between theory and experiment is emphasized, and a special chapter on ‘Fractals and Experiment’ presents experimental studies of fractal systems. This second edition has been substantially revised and updates the literature in this important field. It is pedagogically written and so will be useful for students, teachers, and scientists who want to become familiar with this facinating subject.

Fractals and Disordered Systems - Second Edition

Chaos

Chaos

This eleventh volume in the Poincar Seminar Series presents an interdisciplinary perspective on the concept of Time, which poses some of the most challenging questions in science. Five articles, written by the Fields medalist C. Villani, the two outstanding theoretical physicists T. Damour and C. Jarzynski, the leading experimentalist C. Salomon, and the famous philosopher of science H. Price, describe recent developments related to the mathematical, physical, experimental, and philosophical facets of this fascinating concept. These articles are also highly pedagogical, as befits their origin in lectures to a broad scientific audience. Highlights include a description of the manifold fundamental physical issues in play with time, in particular with the changes of perspective implied by Special and General Relativity; a mathematically precise discussion of irreversibility and entropy in the context of Boltzmann’s and Vlasov’s equations; a thorough survey of the recently developed thermodynamics at the nanoscale, the scale most relevant to biological physics; a description of the new cold atom space clock PHARAO to be installed in 2015 onboard the International Space Station, which will allow a test of Einstein’s gravitational shift with a record precision of 2 10-6, and enable a test of the stability over time of the fundamental constants of physics, an issue first raised by Dirac in 1937; and last, but not least, a logical and clarifying philosophical discussion of Time’s arrow, a phrase first coined by Eddington in 1928 in a challenge to physics to resolve the puzzle of the time-asymmetry of our universe, and echoed here in a short pome en prose by C. de Mitry. This book should be of broad general interest to physicists, mathematicians, and philosophers.

Chaos

Development and Engineering of Dopamine Neurons

Development and Engineering of Dopamine Neurons

The neurotransmitter dopamine has just celebrated its 50th birthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransmitter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbrain dopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and their projections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization of Nurr1 and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins that have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminal differentiation and finally maintenance of the mdDA neuronal pool. In addition, work showing that the historically distinguished regions of the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA ) harbor molecularly distinct sets of neuronal groups with specific connectivity patterns has added a new layer ofcomplexity to how mdDA neurons are generated and function in the adult CNS. The current challenge in the field of dopamine research is to characterize the full extent of molecular processes that underlie mdDA neuron programming and to translate these findings into viable approaches for embryonic stem (ES)-cell engineering as an ultimate treatment of degenerative diseases as Parkinsons disease. The chapters presented in this book provide an overview of the different stages that are distinguished during mdDA neuronal development. Chapter 1 discusses the dopamine systems of the zebrafish, being a powerful model organism for genetic intervention on the developmental programming of neuronal systems. In Chapter 2 an overview is presented of dopamine systems that are present in the vertebrate CNS. Chapters 3-6 discuss the early specification of dopamine precursors and the programs that lead to terminal differentiation. In Chapters 7 and 8 the maintenance of dopamine neurons is discussed with a special emphasis on neurotrophic support. The specific connectivity of the dopamine system and the axon guidance rules that apply to developing dopamine neurons are described in Chapter 9. An overview of ES-cell engineering of dopamine neurons is presented in Chapters 10 and 11. The research directed towards unraveling the molecular programming of mdDA neurons continues to be highly exciting. One may expect that novel biological principles will continue to emerge from this population of neurons. In the near future the field as a whole will mature towards a more comprehensive understanding of mdDA neuronal development and network integration, and will continue to apply knowledge of dopamine neuron development and function to the treatment of human disease.

Development and Engineering of Dopamine Neurons

A Systems Description of Flow Through Porous Media

A Systems Description of Flow Through Porous Media

This text forms part of material taught during a course in advanced reservoir simulation at Delft University of Technology over the past 10 years. The contents have also been presented at various short courses for industrial and academic researchers interested in background knowledge needed to perform research in the area of closed-loop reservoir management, also known as smart fields, related to e.g. model-based production optimization, data assimilation (or history matching), model reduction, or upscaling techniques. Each of these topics has connections to system-theoretical concepts. The introductory part of the course, i.e. the systems description of flow through porous media, forms the topic of this brief monograph. The main objective is to present the classic reservoir simulation equations in a notation that facilitates the use of concepts from the systems-and-control literature. Although the theory is limited to the relatively simple situation of horizontal two-phase (oil-water) flow, it covers several typical aspects of porous-media flow. The first chapter gives a brief review of the basic equations to represent single-phase and two-phase flow. It discusses the governing partial-differential equations, their physical interpretation, spatial discretization with finite differences, and the treatment of wells. It contains well-known theory and is primarily meant to form a basis for the next chapter where the equations will be reformulated in terms of systems-and-control notation.

A Systems Description of Flow Through Porous Media

Frontiers in Statistical Quality Control 10

Frontiers in Statistical Quality Control 10

The 10th International Workshop on Intelligent Statistical Quality Control took place in Seattle, USA, Aug 18-20, 2010. It was hosted by Professor C. M. Mastrangelo, Department of Industrial and Systems Engineering, University of Washington, Seattle. The workshop was jointly organized by Professors H. J. Lenz, C. M. Mastrangelo, W. Schmid and P.T. Wilrich. The twenty-seven papers in this volume were carefully selected by the scientific program committee, reviewed by its members, revised by the authors and, finally, adapted for this volume by the editors.The book is divided into two parts: Part I ‘On-line Control’ covers fields like control charting, monitoring and surveillance as well as acceptance sampling. Part II ‘Off-line Control’ is devoted to experimental design, process capability analysis and data quality.The purpose of the book is on the one hand to provide insights into important new developments in the area of statistical quality control especially surveillance and monitoring and on the other hand to critically discuss methods used in on-line and off-line statistical quality control.

Frontiers in Statistical Quality Control 10

Four Miles to Freedom

Four Miles to Freedom

When Flight Lieutenant Dilip Parulkar was shot down over Pakistan on 10 December 1971, he quickly turned that catastrophe into the greatest adventure of his life. On 13 August 1972, Parulkar, along with Malvinder Singh Grewal and Harish Sinhji, escaped from a POW camp in Rawalpindi. Four Miles to Freedom is their story. Based on interviews with eight Indian fighter pilots who helped prepare the escape and the two who escaped, as well as research into other sources, Four Miles is also the moving, sometimes amusing, account of how twelve fighter pilots from different ranks and backgrounds coped with deprivation, forced intimacy, and the pervasive uncertainty of a year in captivity, and how they came together to support Parulkars courageous escape plan.

Four Miles to Freedom

The New ICT Ecosystem

The New ICT Ecosystem

The ICT sector is crucial as a driver of economic and social growth. Not only is it an important industry in its own right, but it also provides the communication and infrastructure without which modern economies could not function. How does this sector work? Why is it stronger in some countries than in others? What should companies, governments and regulators be doing to enhance its contribution? In The New ICT Ecosystem, Martin Fransman answers these and other questions by developing the idea of the ICT sector as an evolving ecosystem. He shows that some components of the ICT ecosystem, particularly the innovation process, work better in some countries and regions than in others. For example, the Internet content and applications layer of the ecosystem tends to work better in the US than in Europe or Asia. The analysis in this book enables policy makers and regulators to understand why some parts of the ICT ecosystem are underperforming and what can be done to enhance their performance. The previous edition of The New ICT Ecosystem won the 2008-10 Joseph Schumpeter Prize. Winner of the 2008-10 Joseph Schumpeter Prize Presents a highly original analysis of the ICT sector based on the metaphor of an evolving ecosystem Provides important advice to policy makers and regulators about how underperforming parts of of the ICT sector can be improved

The New ICT Ecosystem

Carp and Pond Fish Culture, Second Edition

Carp and Pond Fish Culture, Second Edition

During the 10 years since publication of the first edition of this well-recieved book, the carp and pond fish farming industry has continued to grow steadily. Fully revised and updated, this comprehensive new edition provides a detailed and practical guide to the principles and practices of farming cyprinid fish, using traditional and modern pond culture techniques.

Carp and Pond Fish Culture, Second Edition

Functional Materials and Biomaterials

Functional Materials and Biomaterials

This book has the highest impact factor of all publications ranked by ISI within polymer science. It contains short and concise reports on physics and chemistry of polymers, each written by the world renowned experts. It remains valid and useful after 5 or 10 years. The electronic version is available free of charge for standing order customers at: springer.com/series/12/.

Functional Materials and Biomaterials

Algarve

Algarve

DK Eyewitness Top 10 Travel Guide Algarve will lead you straight to the best attractions this beautiful region has to offer. Whether you’re looking for lively nightlife, want to enjoy the stunning beaches along the rugged coastline or to simply unwind by enjoying a round of golf on one of the many courses, this travel guide is packed with essential information for every traveller – whatever your budget. The nature of this guide makes it effortless to get the best of the Algarve at a glance, with dozens of Top 10 lists to help you make your way around the area: from the Top 10 resorts and the Top 10 restaurants, to the Top 10 best golf courses and even the Top 10 things to avoid. Packed with beautiful illustrations of the greatest attractions, the Top 10 Guide helps you explore every corner of the Algarve with ease.

Algarve

Handbook on the Physics and Chemistry of Rare Earths Volume 10

Handbook on the Physics and Chemistry of Rare Earths Volume 10

0

Handbook on the Physics and Chemistry of Rare Earths Volume 10

Mac OS X Snow Leopard: The Missing Manual

Mac OS X Snow Leopard: The Missing Manual

For a company that promised to ‘put a pause on new features,’ Apple sure has been busy-there’s barely a feature left untouched in , OS X 10.6 ‘Snow Leopard.’ There’s more speed, more polish, more refinement-but still no manual. Fortunately, David Pogue is back, with the humor and expertise that have made this the #1 bestselling Mac book for eight years straight.

Mac OS X Snow Leopard: The Missing Manual