Engineering in Translational Medicine

Engineering in Translational Medicine

This book covers a broad area of engineering research in translational medicine. Leaders in academic institutions around the world contributed focused chapters on a broad array of topics such as: cell and tissue engineering (6 chapters), genetic and protein engineering (10 chapters), nanoengineering (10 chapters), biomedical instrumentation (4 chapters), and theranostics and other novel approaches (4 chapters). Each chapter is a stand-alone review that summarizes the state-of-the-art of the specific research area.

Engineering in Translational Medicine

Algorithms in Bioinformatics

Algorithms in Bioinformatics

An improved model for statistical alignment (I. Mikls, Z. Toroczkai). Improving profile-profile alignments via log average scoring (N. von ohsen, R. Zimmer). False positive s in genomic map assembly and sequence validation (T. Anantharaman, B. Mishra). Boosting EM for radiation hybrid and genetic mapping (T. Schiex, P. Chabrier, M. Bouchez, D. Milan). Placing probes along the genome using pairwise distance data (W. Casey, B. Mishra, M. Wigler). Comparing a Hidden Markov model and a stochastic context-free grammar (A. Jagota, R. B. Lyngso, C. N. S. Pedersen). Assessing the statistical significance of overrepresented oligonucleotides (A. Denise, M. Rgnier, M. vandenbogaert). Pattern matching and pattern discovery algorithms for protein topologies (J. Viksna, D. Gilbert). Computing linking numbers of a filtration (H. Edelsbrusnner, A. Zomorodian). Side chain-positioning as an integer programming problem (O. Eriksson, Y. Zhou, A. Elofsson). A chemical-distance-based test for positive darwinian selection (T. Pupko, R. Sharan, M. Hasegawa, R. Shamir, D. Graur). Finding a maximum compatible tree for a bounded number of trees with bounded degree is solvable in polynominal time (G. Ganapathysaravanabavan, T. Warnow). Experiments in computing sequences of reversals (A. Bergeron, Franois Strasbourg). Exact-IEBP: a new technique for estimating evolutionary distances between whole genomes (Li-San Wang). Finding an optimal inversion median: experimental results (A. C. Siepel, B. M. E. Moret). Analytic solutions for three-taxon MLMC trees with variable rates across sites (B. Chor, M. Hendy, D. Penny). The performance of phylogenetic methods on trees of bounded diameter (L. nakhleh, U. Roshan, K. St. John, J. Sun, T. Warnow). (1+E)- approximation of sorting by reversals and transpositions (N. Eriksen). On the practical solution of the reversal median problem (A. Caprara). Algorithms for finding gene clusters (S. Heber, J. Stoye). Determination of binding amino acids based on random peptide array screening data (P. J. van der Veen, L. F. A. Wessels, J. W. Sloostra, R. H. Meloen, M. J. T. Reinders, J. Hellendoorn). A simple hyper-geometric approach for discovering putative transcription factor binding sites (Y. Barash, G. Bejerano, N. Friedman). Comparing assemblies using fragments and mate-pairs (D. H. Huson, A. L. Halpern, Z. Lai, E. W. myers, K. Reinert, G. G. Sutton). Author index.

Algorithms in Bioinformatics

A History of Architecture

A History of Architecture

When the late Spiro Kostof’s A History of Architecture appeared in 1985, it was universally hailed as a masterpiece–one of the finest books on architecture ever written. Now, updated and expanded, this classic reference continues to bring to readers the full array of civilization’s architectural achievements.

A History of Architecture

Italian Mathematics Between the Two World Wars

Italian Mathematics Between the Two World Wars

This book describes Italian mathematics in the period between the two World Wars. We analyze its development by focusing on both the interior and the external influences. Italian mathematics in that period was shaped by a colorful array of strong personalities who concentrated their efforts on a select number of fields and won international recognition and respect in an incredibly short time. Consequently, Italy was considered a third ‘mathematical power’ after France and Germany, and qualified Italian universities became indispensable stops on the ‘tour’, organized for the improvement of young foreign mathematicians. At that time, Italy was also dominated by a fascist regime. This political situation and the social and academic structure of Italian society are included in the analysis as influences external to mathematics itself. The authors have provided a fascinating study of a most difficult time in the history of the world and of mathematics.

Italian Mathematics Between the Two World Wars

Bilingual Youth

Bilingual Youth

The present volume represents a variety of portraits of what happens when families attempt to raise children in Spanish while living in English-speaking societies. Aided by the foregrounding chapter by Suzanne Romaine about language and identity and the afterword by Carol Klee that ties together many issues brought up throughout the collection, the reader gains a more complete understanding of the variables that contribute to Spanish bilingualism in English-speaking societies, and by extension a more complete understanding of the dynamic nature of bilingualism in general. This volume, the first of its kind, brings together an impressive array of sociolinguistic environments while keeping the two languages constant. We hope that it marks the beginning of comparative analyses of bilingualism, acquisition outcomes, and identity construction across environments that share the same languages, but where important disparities exist in the sociolinguistic landscapes.

Bilingual Youth

The Wit and Wisdom of G K Chesterton

The Wit and Wisdom of G K Chesterton

G.K. Chesterton was a consummately witty man. In this new collection, Bevis Hillier draws on his most humorous epigrams and more serious extracts not only from his most popular works, the Father Brown stories, but also his contributions to the Illustrated London News and GK’s Weekly, as well as his numerous novels, poems, essays and tracts on a vast array of subjects. These pieces shine a light into the margins of Chesterton’s work and give a sense of the distinctive flavour of his mind. Hillier, the acclaimed biographer of John Betjeman, considers what it was that made Chesterton such a complex and fascinating character. Some of Chesterton’s remarkable drawings (he trained as an artist at the Slade) are included, among them a hitherto unpublished caricature of Winston Churchill, c. 1919. This is a book for Chesterton fans everywhere.

The Wit and Wisdom of G K Chesterton

Eat My Globe

Eat My Globe

Eat My Globe is a culinary tour of the world that Simon has always dreamed of making. From Philly Cheese steak in the US to mouldy shark in Iceland, he crosses the globe in search of variety and the ultimate taste experience. He also meets a fascinating array of people, whose foodie passion impresses even Simon. Some content on Sydney.

Eat My Globe

Portland, Oregon Chefs Table

Portland, Oregon Chefs Table

Portland, Oregon Chef’s Tablecelebrates the food and culture of what theNew York Timescalls the city’s ‘golden age’ of dining and drinking. The city’s food scene–largely a celebration of the farm-to-table movement–has grown and evolved tremendously in the last five years, with an abundance of local fisheries, farms, and small beef, lamb, and pork producers providing the city’s fascinating restaurants with a wide array of locally-grown deliciousness.

Portland, Oregon Chefs Table

Angiogenesis and Anti-Angiogenesis in Hematological Malignancies

Angiogenesis and Anti-Angiogenesis in Hematological Malignancies

It has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. The extent of angiogenesis in the bone marrow has been correlated with disease burden, prognosis and treatment outcome. Reciprocal positive and negative interactions between tumor cells and bone marrow stromal cells, namely hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts, endothelial cells, endothelial progenitor cells, T cells, macrophages and mast cells, mediated by an array of cytokines, receptors and adhesion molecules, modulate the angiogenic response in hematological tumors. More recently, it has been emphasized the pro-angiogenic role of the so called vascular niche, indicating a site rich in blood vessels where endothelial cells and mural cells such as pericytes and smooth muscle cells create a microenvironment that affects the behavior of several stem and progenitor cells, in hematological malignancies.

Angiogenesis and Anti-Angiogenesis in Hematological Malignancies

Beginning Python

Beginning Python

Gain a fundamental understanding of Pythons syntax and features with the second edition of Beginning Python, an uptodate introduction and practical reference. Covering a wide array of Pythonrelated programming topics, including addressing language internals, database integration, network programming, and web services, youll be guided by sound development principles. Ten accompanying projects will ensure you can get your hands dirty in no time.

Beginning Python

Cross-Linked Liquid Crystalline Systems

Cross-Linked Liquid Crystalline Systems

Liquid crystal displays were discovered in the 1960s, and today we continue to enjoy the benefits of that fundamental discovery and its translation into a wide variety of products. Like liquid crystals, polymers are unusual materials, and have similarly enjoyed a great deal of research attention because of their vast applications and uses and complex fundamental properties. The combination of liquid crystal and polymer properties produces a broad array of new effectsspanning from densely crosslinked, rigid polymer networks to weakly crosslinked elastomersthat are not simply manifestations of either native liquid crystals or polymers alone.

Cross-Linked Liquid Crystalline Systems

Mendelssohn, Goethe and the Walpurgis Night

Mendelssohn, Goethe and the Walpurgis Night

Mendelssohn, Goethe, and the Walpurgis Night addresses tolerance and acceptance in the face of cultural, political, and religious strife. Its point of departure is the Walpurgis Night. The Night, also known as Beltane or May Eve, was supposedly an annual witches’ Sabbath that centered around the Brocken, the highest peak of the Harz Mountains. After exploring how a notoriously pagan celebration came to be named after the Christian missionary St. Walpurgis (ca. 710-79), John Michael Cooper discusses the Night’s treatments in several closely interwoven works by Goethe and Mendelssohn. His book situates those works in their immediate personal and professional contexts, as well as among treatments by a wide array of other artists, philosophers, and political thinkers, including Voltaire, Lessing, Shelley, Heine, Delacroix, and Berlioz. In an age of decisive political and religious conflict, Walpurgis Night became a heathen muse: a source of spiritual inspiration that was neither specifically Christian, nor Jewish, nor Muslim. And Mendelssohn’s and Goethe’s engagements with it offer new insights into its role in European cultural history, as well as into issues of political, religious, and social identity — and the relations between cultural groups — in today’s world. John Michael Cooper is Professor of Music at Southwestern University and author of Mendelssohn’s ‘Italian’ Symphony (Oxford University Press).

Mendelssohn, Goethe and the Walpurgis Night

Insect Life Cycles

Insect Life Cycles

The International Congress of Entomology holds regular symposia on insect life-cyles every four years. This book arose from papers contributed by most of the speakers at the latest symposium held in Vancouver, BC (Canada), July 1988. This volume provides a diverse array of studies on insect life-cycle evolution which can be broken down into three main levels of approach: (a) comparisons of genetic variation and covariation underlying life-cycle traits; (b) comparisons of variable phenotypes within and among populations of the same and/or related species; and (c) comparisons of habitat-specific traits regardless of relatedness. While the material is particularly relevant to scientists and researchers within this field, both undergraduate and graduate level students will find the material relevant to their studies.

Insect Life Cycles

Lectures on Quantum Mechanics

Lectures on Quantum Mechanics

Beautifully illustrated and engagingly written, Twelve Lectures in Quantum Mechanics presents theoretical physics with a breathtaking array of examples and anecdotes. Basdevants style is clear and stimulating, in the manner of a brisk lecture that can be followed with ease and enjoyment. Here is a sample of the books style, from the opening of Chapter 1: ‘If one were to ask a passer-by to quote a great formula of physics, chances are that the answer would be E = mc2. There is no way around it: all physics is quantum, from elementary particles, to stellar physics and the Big Bang, not to mention semiconductors and solar cells.’

Lectures on Quantum Mechanics

Microsoft Windows Communication Foundation 4.0 Cookbook for Developing SOA Applications

Microsoft Windows Communication Foundation 4.0 Cookbook for Developing SOA Applications

WCF 4.0 is a communications infrastructure that unifies a broad array of distributed systems’ capabilities in a composable, extensible architecture that supports multiple transports, messaging patterns, encodings, , topologies, and hosting models. This book is a collection of focused real-world recipes and covers , recipes on topics such as working with contracts to more advanced topics such as extending WCF runtime. By the end of this book you will have valuable information that helps transform the potentially unproductive habits of , developers who work with WCF.,

This book will take you through many concepts starting with complete support for contract-related design for WCF service development. You will learn to use WCF’s built-in feature for building various service endpoints.

Microsoft Windows Communication Foundation 4.0 Cookbook for Developing SOA Applications