New Directions in Nursing History

New Directions in Nursing History

This collection of essays reflects the current interdisciplinary and international nature of the history of nursing scholarship.

New Directions in Nursing History

Why Society is a Complex Matter

Why Society is a Complex Matter

Society is complicated. But this book argues that this does not place it beyond the reach of a science that can help to explain and perhaps even to predict social behaviour. As a system made up of many interacting agents people, groups, institutions and governments, as well as physical and technological structures such as roads and computer networks society can be regarded as a complex system. In recent years, scientists have made great progress in understanding how such complex systems operate, ranging from animal populations to earthquakes and weather. These systems show behaviours that cannot be predicted or intuited by focusing on the individual components, but which emerge spontaneously as a consequence of their interactions: they are said to be self-organized. Attempts to direct or manage such emergent properties generally reveal that top-down approaches, which try to dictate a particular outcome, are ineffectual, and that what is needed instead is a bottom-up approach that aims to guide self-organization towards desirable states. This book shows how some of these ideas from the science of complexity can be applied to the study and management of social phenomena, including traffic flow, economic markets, opinion formation and the growth and structure of cities. Building on these successes, the book argues that the complex-systems view of the social sciences has now matured sufficiently for it to be possible, desirable and perhaps essential to attempt a grander objective: to integrate these efforts into a unified scheme for studying, understanding and ultimately predicting what happens in the world we have made. Such a scheme would require the mobilization and collaboration of many different research communities, and would allow society and its interactions with the physical environment to be explored through realistic models and large-scale data collection and analysis. It should enable us to find new and effective solutions to major global problems such as conflict, disease, financial instability, environmental despoliation and poverty, while avoiding unintended policy consequences. It could give us the foresight to anticipate and ameliorate crises, and to begin tackling some of the most intractable problems of the twenty-first century.

Why Society is a Complex Matter

Biomechanics of the Gravid Human Uterus

Biomechanics of the Gravid Human Uterus

The complexity of human uterine function and regulation is one of the great wonders of nature and represents a daunting challenge to unravel. This book is dedicated to the biomechanical modeling of the gravid human uterus and gives an example of the application of the mechanics of solids and the theory of soft shells to explore medical problems of labor and delivery. After a brief overview of the anatomy, physiology and biomechanics of the uterus, the authors focus mainly on electromechanical wave processes, their origin, dynamics, and neuroendocrine and pharmacological modulations. In the last chapter applications, pitfalls and problems related to modeling and computer simulations of the pregnant uterus and pelvic floor structures are discussed. A collection of exercises is added at the end of each chapter to help readers with self-evaluation. The book serves as an invaluable source of information for researchers, instructors and advanced undergraduate and graduate students interested in systems biology, applied mathematics and biomedical engineering.

Biomechanics of the Gravid Human Uterus

Gene Therapy

Gene Therapy

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. Volume 40, GeneTherapy, features important new research on gene transfers and therapy in the herpes simplex virus, anti-tumor immunity, steroid receptors, cystic fibroses, and more.

Gene Therapy

The Edge of Reason?

The Edge of Reason?

inspire spiritual wonder? Confrontation between science and religion has defined much public debate about religion in recent years, most lately in bestsellers portraying a clash between scientists and religious believers, such as Richard Dawkins’ ‘The God Delusion ‘and Sam Harris’s ‘The End of Faith ‘or ‘Letter to a Christian Nation.’ But what does this ‘us versus them’ divide mean for society? This collection of essays gives voice to social scientists, natural scientists and theologians whose experience holds direct relevance on these major issues, and clarifies the position of science in the modern debate. Includes contributions by Mary Midgley (University of Newcastle Upon Tyne, UK), Denis Alexander (Cambridge University, UK), Richard Roberts (Lancaster University, UK), Bob Layton (Durham University, UK), Simon Coleman (Sussex University, UK), Michael Shermer (Executive Director of the Sceptics Society and monthly columnist for ‘Scientific American’), Lewis Wolpert (University College London, UK), Andrew Newberg (University of Pennsylvania), Timothy Taylor (University of Bradford, UK), Steven Mithen (University of Reading, UK), David Sloan Wilson (Binghamton University), Herbert Maschner (Idaho State University), Ian Reader (University of Manchester, UK), Hiroko Kawanami (Lancaster University, UK), Andrian Kreye (Suddeutsche Zeitung), John Hedley Brooke (Oxford University, UK), Gordy Slack (Author of ‘The Battle Over The Meaning Of Everything’), Seth Shostak (Seti Institute), William Calvin (University Of Washington), and David Wilkinson (Durham University, UK).

The Edge of Reason?

Guide to Cisco Routers Configuration

Guide to Cisco Routers Configuration

This work provides a guide to the configuration of Cisco routers, from tasks for beginners to advanced operations. A collection of detailed ‘how-to’ instructions are presented, which will be of use to all professionals and students who engage with Cisco routers in the field or in the lab. The guide starts with the simple step-by-step task of connecting the router and performing basic configuration, before building up to complex and sensitive operations such as router IOS upgrade and Site-to-Site VPNs.

Guide to Cisco Routers Configuration

Clockwork Fairy Tales

Clockwork Fairy Tales

Combining the timeless fairy tales that we all read as children with the out-of-time technological wizardry that is steampunk, this collection of stories blends the old and the new in ways sure to engage every fantasy reader.?

Clockwork Fairy Tales

A Guide to Being Born Stories

A Guide to Being Born Stories

Reminiscent of Aimee Bender and Karen Russellan enthralling new collection that uses the world of the imagination to explore the heart of the human condition.

A Guide to Being Born Stories

Spinoza Now

Spinoza Now

What does it mean to think about, and with, Spinoza today? This collection, the first broadly interdisciplinary volume dealing with Spinozan thought, asserts the importance of Spinozas philosophy of immanence for contemporary cultural and philosophical debates.

Spinoza Now

Methods of Demographic Analysis

Methods of Demographic Analysis

This book provides an up-to-date overview of demographic analysis and methods, including recent developments in demography. Concepts and methods, from the nature of demographic information through data collection and the basics of statistical measures and on to demographic analysis itself are succinctly explained. Measures and analyses of fertility, mortality, life tables, migration and demographic events such as marriage, education and labour force are described while later chapters cover multiple decrement tables, population projections, the importance of testing and smoothing demographic data, the stable population model and demographic software.

Methods of Demographic Analysis

The Brain is the Screen

The Brain is the Screen

In the nearly twenty years since their publication, Gilles Deleuze’s books about cinema have proven as daunting as they are enticing — a new aesthetics of film, one equally at home with Henri Bergson and Wim Wenders, Friedrich Nietzsche and Orson Welles, that also takes its place in the philosopher’s immense and difficult oeuvre. With this collection, the first to focus solely and extensively on Deleuze’s cinematic work, the nature and reach of that work finally become clear. Composed of a substantial introduction, twelve original essays produced for this volume, and a new English translation of a personal, intriguing, and little-known interview with Deleuze on his cinema books, The Brain Is the Screen is a sustained engagement with Deleuze’s cinematic philosophy that leads to a new view of the larger confrontation of philosophy with cinematic images.

The Brain is the Screen

Clusters in Nuclei, Volume 1

Clusters in Nuclei, Volume 1

Following the pioneering discovery of alpha clustering and of molecular resonances, the field of nuclear clustering is presently one of the domains of heavy-ion nuclear physics facing both the greatest challenges and opportunities. After many summer schools and workshops, in particular over the last decade, the community of nuclear molecular physics decided to team up in producing a comprehensive collection of lectures and tutorial reviews covering the field. This first volume, gathering seven extensive lectures, covers the follow topics: * Cluster Radioactivity * Cluster States and Mean Field Theories * Alpha Clustering and Alpha Condensates * Clustering in Neutron-rich Nuclei * Di-neutron Clustering * Collective Clusterization in Nuclei * Giant Nuclear Molecules By promoting new ideas and developments while retaining a pedagogical nature of presentation throughout, these lectures will both serve as a reference and as advanced teaching material for future courses and schools in the fields of nuclear physics and nuclear astrophysics.

Clusters in Nuclei, Volume 1

Philosophical Faith and the Future of Humanity

Philosophical Faith and the Future of Humanity

Karl Jaspers, who died in 1969, had a profound impact on 20th-century theology and philosophy. His central thesis called for, among other things, a de-centering of philosophy from its Eurocentric roots and a renewal of its dialogue with other traditions, especially Asian ones. This collection of essays includes unpublished work by Jaspers himself as well as testimonies to his life and career by colleagues, associates, and translators, some of who knew Jaspers personally. Readers will also find commentary and interpretation by researchers who have explored Jaspers work for decades, and a biographical account of Jaspers student Leonard Ehrlich, who handled much of Jaspers English translation.

Philosophical Faith and the Future of Humanity

Agent-Based Models of Geographical Systems

Agent-Based Models of Geographical Systems

This unique book brings together a comprehensive set of papers on the background, theory, technical issues and applications of agent-based modelling (ABM) within geographical systems. This collection of papers is an invaluable reference point for the experienced agent-based modeller as well those new to the area. Specific geographical issues such as handling scale and space are dealt with as well as practical advice from leading experts about designing and creating ABMs, handling complexity, visualising and validating model outputs. With contributions from many of the world s leading research institutions, the latest applied research (micro and macro applications) from around the globe exemplify what can be achieved in geographical context. This book is relevant to researchers, postgraduate and advanced undergraduate students, and professionals in the areas of quantitative geography, spatial analysis, spatial modelling, social simulation modelling and geographical information sciences.

Agent-Based Models of Geographical Systems

Clusters in Nuclei, Volume 3

Clusters in Nuclei, Volume 3

Following the pioneering discovery of alpha clustering and of molecular resonances, the field of nuclear clustering is today one of those domains of heavy-ion nuclear physics that faces the greatest challenges, yet also contains the greatest opportunities. After many summer schools and workshops, in particular over the last decade, the community of nuclear molecular physicists has decided to collaborate in producing a comprehensive collection of lectures and tutorial reviews covering the field. This third volume follows the successful Lect. Notes Phys. 818 (Vol. 1) and 848 (Vol. 2), and comprises six extensive lectures covering the following topics:

Clusters in Nuclei, Volume 3

The Edge of the Precipice

The Edge of the Precipice

Can a case be made for reading literature in the digital age? Does literature still matter in this era of instant information? Is it even possible to advocate for serious, sustained reading with all manner of social media distracting us, fragmenting our concentration, and demanding short, rapid communication? In The Edge of the Precipice, Paul Socken brings together a thoughtful group of writers, editors, philosophers, librarians, archivists, and literary critics from Canada, the US, France, England, South Africa, and Australia to contemplate the state of literature in the twenty-first century. Including essays by outstanding contributors such as Alberto Manguel, Mark Kingwell, Lori Saint-Martin, Sven Birkerts, Katia Grubisic, Drew Nelles, and J. Hillis Miller, this collection presents a range of perspectives about the importance of reading literature today. The Edge of the Precipice is a passionate, articulate, and entertaining collection that reflects on the role of literature in our society and asks if it is now under siege. Contributors include Michael Austin (Newman University), Sven Birkerts (author), Stephen Brockmann (Carnegie-Mellon University), Vincent Giroud (University of Franche-Comt), Katia Grubisic (poet), Mark Kingwell (University of Toronto), Alberto Manguel (author), J. Hillis Miller (University of California, Irvine), Drew Nelles (editor-in-chief, Maisonneuve), Keith Oatley (University of Toronto), Ekaterina Rogatchevskaia (British Library), Leonard Rosmarin (Brock University), Lori Saint-Martin (translator), Paul Socken (University of Waterloo), and Gerhard van der Linde (University of South Africa).

The Edge of the Precipice

Development and Engineering of Dopamine Neurons

Development and Engineering of Dopamine Neurons

The neurotransmitter dopamine has just celebrated its 50th birthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransmitter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbrain dopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and their projections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization of Nurr1 and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins that have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminal differentiation and finally maintenance of the mdDA neuronal pool. In addition, work showing that the historically distinguished regions of the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA ) harbor molecularly distinct sets of neuronal groups with specific connectivity patterns has added a new layer ofcomplexity to how mdDA neurons are generated and function in the adult CNS. The current challenge in the field of dopamine research is to characterize the full extent of molecular processes that underlie mdDA neuron programming and to translate these findings into viable approaches for embryonic stem (ES)-cell engineering as an ultimate treatment of degenerative diseases as Parkinsons disease. The chapters presented in this book provide an overview of the different stages that are distinguished during mdDA neuronal development. Chapter 1 discusses the dopamine systems of the zebrafish, being a powerful model organism for genetic intervention on the developmental programming of neuronal systems. In Chapter 2 an overview is presented of dopamine systems that are present in the vertebrate CNS. Chapters 3-6 discuss the early specification of dopamine precursors and the programs that lead to terminal differentiation. In Chapters 7 and 8 the maintenance of dopamine neurons is discussed with a special emphasis on neurotrophic support. The specific connectivity of the dopamine system and the axon guidance rules that apply to developing dopamine neurons are described in Chapter 9. An overview of ES-cell engineering of dopamine neurons is presented in Chapters 10 and 11. The research directed towards unraveling the molecular programming of mdDA neurons continues to be highly exciting. One may expect that novel biological principles will continue to emerge from this population of neurons. In the near future the field as a whole will mature towards a more comprehensive understanding of mdDA neuronal development and network integration, and will continue to apply knowledge of dopamine neuron development and function to the treatment of human disease.

Development and Engineering of Dopamine Neurons

The Neuroscience of Sleep

The Neuroscience of Sleep

Sleep is the natural state of bodily rest, common to all mammals and birds and also seen in many reptiles, amphibians and fish. For most species, regular sleep is essential for survival, yet the specific purposes of sleep are still only partly clear and are the subject of intense research. This volume is comprised of the editors’ selection of the most relevant articles on sleep from the Encyclopedia of Neuroscience, resulting in the first comprehensive collection of introductory articles on the neuroscience of sleep. Articles explore sleep’s impact on neural functioning, sleep disorders, the relation between sleep and other clinical disorders, a look at sleep from a developmental perspective, and more.

The Neuroscience of Sleep

Acidity and Basicity

Acidity and Basicity

This is the first handbook on zeolites and other microporous materials. It is an up-to-date, highly sophisticated collection of information for those who deal with zeolites in industry or at academic institutions as well as being a guide for newcomers.

Acidity and Basicity

Inspirational Quotes Ultimate Collection

Inspirational Quotes Ultimate Collection

INSPIRATIONAL QUOTES ULTIMATE COLLECTION

Inspirational Quotes Ultimate Collection