Algorithms in Bioinformatics

Algorithms in Bioinformatics

An improved model for statistical alignment (I. Mikls, Z. Toroczkai). Improving profile-profile alignments via log average scoring (N. von ohsen, R. Zimmer). False positive s in genomic map assembly and sequence validation (T. Anantharaman, B. Mishra). Boosting EM for radiation hybrid and genetic mapping (T. Schiex, P. Chabrier, M. Bouchez, D. Milan). Placing probes along the genome using pairwise distance data (W. Casey, B. Mishra, M. Wigler). Comparing a Hidden Markov model and a stochastic context-free grammar (A. Jagota, R. B. Lyngso, C. N. S. Pedersen). Assessing the statistical significance of overrepresented oligonucleotides (A. Denise, M. Rgnier, M. vandenbogaert). Pattern matching and pattern discovery algorithms for protein topologies (J. Viksna, D. Gilbert). Computing linking numbers of a filtration (H. Edelsbrusnner, A. Zomorodian). Side chain-positioning as an integer programming problem (O. Eriksson, Y. Zhou, A. Elofsson). A chemical-distance-based test for positive darwinian selection (T. Pupko, R. Sharan, M. Hasegawa, R. Shamir, D. Graur). Finding a maximum compatible tree for a bounded number of trees with bounded degree is solvable in polynominal time (G. Ganapathysaravanabavan, T. Warnow). Experiments in computing sequences of reversals (A. Bergeron, Franois Strasbourg). Exact-IEBP: a new technique for estimating evolutionary distances between whole genomes (Li-San Wang). Finding an optimal inversion median: experimental results (A. C. Siepel, B. M. E. Moret). Analytic solutions for three-taxon MLMC trees with variable rates across sites (B. Chor, M. Hendy, D. Penny). The performance of phylogenetic methods on trees of bounded diameter (L. nakhleh, U. Roshan, K. St. John, J. Sun, T. Warnow). (1+E)- approximation of sorting by reversals and transpositions (N. Eriksen). On the practical solution of the reversal median problem (A. Caprara). Algorithms for finding gene clusters (S. Heber, J. Stoye). Determination of binding amino acids based on random peptide array screening data (P. J. van der Veen, L. F. A. Wessels, J. W. Sloostra, R. H. Meloen, M. J. T. Reinders, J. Hellendoorn). A simple hyper-geometric approach for discovering putative transcription factor binding sites (Y. Barash, G. Bejerano, N. Friedman). Comparing assemblies using fragments and mate-pairs (D. H. Huson, A. L. Halpern, Z. Lai, E. W. myers, K. Reinert, G. G. Sutton). Author index.

Algorithms in Bioinformatics

Bitter-Sweet Harvest

Bitter-Sweet Harvest

Set in a Malaysia emerging from the outbreak of racial conflict in 1969, Bitter-Sweet Harvest tells of the difficulties and tensions involved in a marriage between a Malay Muslim and a Chinese Christian. Atmospheric, dramatic, action-packed and intriguing, it is peppered with local flavour evoking the heat, colours and sounds of Southeast Asia. Prepare to be taken on a spell-binding journey through contrasting cultures: from the learned spires of Oxford in England to the east coast of Peninsula Malaysia; from vibrant Singapore to Catholic Rome and developing Indonesia.Bitter-Sweet Harvest is the sequel to the novel Sweet Offerings. The stories can be read in any order and are complete in themselves.

Bitter-Sweet Harvest

Armenian Apocrypha Relating to Abraham

Armenian Apocrypha Relating to Abraham

This volume introduces a cycle of stories about Abraham as preserved in fifteen unpublished, late medieval manuscripts in Armenian, published here in English for the first time with commentaries, annotations, and critical apparatus. The texts present embroidered Abraham stories dealing with his youth, his life in Egypt, the binding of Isaac, the story of Melchizedek, and other tales. Embedding Jewish, Christian, Islamic, and other ancient traditions, these texts demonstrate mutual borrowing and influence over centuries.

Armenian Apocrypha Relating to Abraham

Essential Quantum Physics

Essential Quantum Physics

This is a first course on quantum mechanics and describes simple applications to physical phenomena that are of immediate and everyday interest. The first five chapters introduce the fundamentals of quantum mechanics and are followed by a quiz so readers can test themselves. The remaining chapters describe applications, including the physics of lasers, molecular binding, simple properties of crystalline solids arising from their band structure, and the operation of junction transistors. This new expanded edition now includes a chapter on the theory of spin and its application to magnetic resonance imaging, as well as a description of the WKB approximation and its application to alpha decay. Ideal either as a course text or a self-study text, the book contains nearly 100 exercises and hints to their solution.

Essential Quantum Physics

Calcium Signalling in Cancer

Calcium Signalling in Cancer

Calcium signalling occupies a preeminent position in the signal transduction system of the cell by virtue of its participation in a wide range of physiological functions together with the biological events associated with genetic expression, cell proliferation and apoptosis, as well as cell differentiation and morphogenesis. It is an important feature of cell adhesion and motility; the integrity of the calcium binding proteins themselves is a basic requirement of normal biological function. In fact, the deregulation of calcium signaling is now regarded as the primary event in the pathogenesis, growth, invasion, and secondary spread of cancer.

Calcium Signalling in Cancer

High-Throughput Screening in Drug Discovery

High-Throughput Screening in Drug Discovery

Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. Chapter authors from leading pharmaceutical companies as well as from Harvard University discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results.

High-Throughput Screening in Drug Discovery