Algorithms in Bioinformatics

Algorithms in Bioinformatics

An improved model for statistical alignment (I. Mikls, Z. Toroczkai). Improving profile-profile alignments via log average scoring (N. von ohsen, R. Zimmer). False positive s in genomic map assembly and sequence validation (T. Anantharaman, B. Mishra). Boosting EM for radiation hybrid and genetic mapping (T. Schiex, P. Chabrier, M. Bouchez, D. Milan). Placing probes along the genome using pairwise distance data (W. Casey, B. Mishra, M. Wigler). Comparing a Hidden Markov model and a stochastic context-free grammar (A. Jagota, R. B. Lyngso, C. N. S. Pedersen). Assessing the statistical significance of overrepresented oligonucleotides (A. Denise, M. Rgnier, M. vandenbogaert). Pattern matching and pattern discovery algorithms for protein topologies (J. Viksna, D. Gilbert). Computing linking numbers of a filtration (H. Edelsbrusnner, A. Zomorodian). Side chain-positioning as an integer programming problem (O. Eriksson, Y. Zhou, A. Elofsson). A chemical-distance-based test for positive darwinian selection (T. Pupko, R. Sharan, M. Hasegawa, R. Shamir, D. Graur). Finding a maximum compatible tree for a bounded number of trees with bounded degree is solvable in polynominal time (G. Ganapathysaravanabavan, T. Warnow). Experiments in computing sequences of reversals (A. Bergeron, Franois Strasbourg). Exact-IEBP: a new technique for estimating evolutionary distances between whole genomes (Li-San Wang). Finding an optimal inversion median: experimental results (A. C. Siepel, B. M. E. Moret). Analytic solutions for three-taxon MLMC trees with variable rates across sites (B. Chor, M. Hendy, D. Penny). The performance of phylogenetic methods on trees of bounded diameter (L. nakhleh, U. Roshan, K. St. John, J. Sun, T. Warnow). (1+E)- approximation of sorting by reversals and transpositions (N. Eriksen). On the practical solution of the reversal median problem (A. Caprara). Algorithms for finding gene clusters (S. Heber, J. Stoye). Determination of binding amino acids based on random peptide array screening data (P. J. van der Veen, L. F. A. Wessels, J. W. Sloostra, R. H. Meloen, M. J. T. Reinders, J. Hellendoorn). A simple hyper-geometric approach for discovering putative transcription factor binding sites (Y. Barash, G. Bejerano, N. Friedman). Comparing assemblies using fragments and mate-pairs (D. H. Huson, A. L. Halpern, Z. Lai, E. W. myers, K. Reinert, G. G. Sutton). Author index.

Algorithms in Bioinformatics

The Strategy Process

The Strategy Process

This book investigates strategy formulation by comparing military & business practices. It assesses whether the strategy process in the business field also prevails in the military context. Based on interviews and case studies, the author uses a framework of influences including organization, leadership, risk, theory and context to consider the areas of similarity and difference. While significant parallels can be found, greater importance is placed on the formulation of aims and goals, and the identification and training of leaders in the military. This provides valuable lessons for business strategists.

The Strategy Process

Principles of Programming Languages

Principles of Programming Languages

The development of programming languages has radically modified our relation to language, complexity and machines. This book is an introduction to the principles around which these languages are organised imperative constructions, functional constructions, reference, dynamic data types, objects and more. Using Java as a main language, but systematically comparing it to other languages it enables the reader to understand the unifying concepts that lie beneath each particular language and provides the tools that allow the students to adapt to new programming languages.

Principles of Programming Languages

How Should One Live?

How Should One Live?

Chinese and Greco-Roman ethics present highly articulate views on how one should live; both of these traditions remain influential in modern philosophy. The question arises how these traditions can be compared with one another. Comparative ethics is a relatively young discipline; this volume is a major contribution to the field. Fundamental questions about the nature of comparing ethics are treated in two introductory chapters, and core issues in each of the traditions are addressed: harmony, virtue, friendship, knowledge, the relation of ethics to morality, relativism, emotions, being and unity, simplicity and complexity, and prediction.

How Should One Live?

Making Sense of NoSQL

Making Sense of NoSQL

If you want to understand and perhaps start using the new data storage and analysis technologies that go beyond the , , model, this book is for you. Written in plain language suitable for technical managers and developers, and using many examples, use cases, and illustrations, this book explains the concepts, features, benefits, potential, and limitations of NoSQL.,

Making Sense of , starts by comparing familiar database concepts to the new NoSQL patterns that augment or replace them. Then, you’ll explore case studies on big data, search, reliability, and business agility that apply these new patterns to today’s business problems. You’ll see how NoSQL systems can leverage the resources of modern cloud computing and multiple-CPU data centers. The final chapters show you how to choose the right NoSQL technologies for your own needs.

Making Sense of NoSQL