An Introduction to Toxicology

An Introduction to Toxicology

This book provides a readable introduction to modern toxicology with a particular focus on the mechanisms underlying the induction of toxicity by foreign substances. Since bioactivation is central to many toxic syndromes, special interest is devoted to chemicals that undergo conversion to toxic metabolites that induce toxic effects as diverse as cancer, birth defects and organ injury. The molecular consequences accompanying damage to cellular DNA and proteins is explored together with the relevance of toxicological paradigms to human diseases caused by alcohol and tobacco. The discipline of toxicology has developed rapidly since the thalidomide disaster in the 1960s as scientists worldwide seek to understand the adverse health effects of human medicines, environmental pollutants, consumer chemicals and industrial reagents. An Introduction to Toxicology is intended to supplement the recommended reading list of undergraduate and graduate programs in toxicology and pharmacology as an enjoyable, accessible primer with illustrations that unpack the concepts being discussed in the text.

An Introduction to Toxicology

Wheels Stop

Wheels Stop

Humanitys first reusable spacecraft and the most complex machine ever built, NASAs Space Shuttle debuted with great promise and as a dependable source of wonder and national pride. But with the Challenger catastrophe in 1986, the whole Space Shuttle program came into question, as did NASA itself, so long an institution that was seemingly above reproach. Wheels Stop tells the stirring story of how, after the Challenger disaster, the Space Shuttle not only recovered but went on to perform its greatest missions. From the Return to Flight mission of STS-26 in 1988 to the last shuttle mission ever on STS-135 in 2011, Wheels Stop takes readers behind the scenes as the shuttles crews begin to mend Cold War tensions with the former Soviet Union, conduct vital research, deploy satellites, repair the Hubble Space Telescope, and assist in constructing the International Space Station. It also tells the heart-wrenching story of the Columbia tragedy and the loss of the magnificent STS-107 crew.

Wheels Stop

Radiation Disaster Medicine

Radiation Disaster Medicine

While many books are available on disaster medicine, none is specifically devoted to the role of physicians in the management of patients exposed to radiation leakage from a damaged nuclear power plant. Radiation Disaster Medicine aims to fill this void based on the response to the Fukushima nuclear accident. Each chapter addresses principles and practices of radiation medicine within the specific context of that accident. Topics covered include the role of physicians in radiation disasters, the concepts of external and internal exposure, prehospital and hospital response, disaster behavioral health, and radiation emergency response from the perspective of national and international institutions. Most of the contributors are active educators and researchers in radiation medicine with first-hand experience in dealing with prehospital triage and management of patients within secondary and tertiary care hospitals in Japan.

Radiation Disaster Medicine

Hyper-V Replica Essentials

Hyper-V Replica Essentials

A fast-paced, step-by-step guide to configuring Hyper-V Replica in various deployment scenarios.a in various deployment scenarios.Hyper-V Replica Essentials is for Windows Server administrators who want to improve their system availability and speed up disaster recovery. You will need experience in Hyper-V deployment because Hyper-V Replica is built in the Hyper-V platform.

Hyper-V Replica Essentials

The Art of SQL

The Art of SQL

For all the buzz about trendy IT techniques, data processing is still at the core of our systems, especially now that enterprises all over the world are confronted with exploding volumes of data. , , has become a major headache, and most IT departments believe that developers should provide simple , code to solve immediate problems and let DBAs tune any ‘bad SQL’ later.,

In The Art of SQL, author and SQL expert Stephane Faroult argues that this ‘safe approach’ only leads to disaster. His insightful book, named after Art of War by Sun Tzu, contends that writing quick inefficient code is sweeping the dirt under the rug.

The Art of SQL

Professional Microsoft SQL Server 2014 Integration Services

Professional Microsoft SQL Server 2014 Integration Services

The 2014 release of Microsoft’s , , Integration Services provides enhancements for managing extraction, transformation, and load operations, plus expanded in-memory capabilities, improved disaster recovery, increased scalability, and much more. The increased functionality will streamline your ETL processes and smooth out your workflow, but the catch is that your workflow must change. New tools come with new best practices, and Professional , SQL Server 2014 Integration Services will keep you ahead of the curve. SQL Server MVP Brian Knight is the most respected name in the business, and your ultimate guide to navigating the changes to use Microsoft SQL Server Integration Services 2014 to your utmost advantage.

Professional Microsoft SQL Server 2014 Integration Services

Pro SharePoint 2013 Administration, 2nd Edition

Pro SharePoint 2013 Administration, 2nd Edition

Pro SharePoint 2013 Administration is a practical guide to , 2013 for intermediate to advanced SharePoint administrators and power users, covering the out-of-the-box feature set and capabilities of Microsoft’s collaboration and , productivity platform.,

Starting with a detailed deployment and initial configuration walkthrough, the book covers all major feature areas, including document management, social computing, metadata management, and administration. You’ll also learn about planning for capacity, backup , and disaster recovery, business intelligence, monitoring, and more. Unlike other books, Pro SharePoint 2013 Administration covers all elements of the product, but has a specific emphasis on features new and enhanced in the 2013 release.

Pro SharePoint 2013 Administration, 2nd Edition

Pro SharePoint 2010 Disaster Recovery and High Availability

Pro SharePoint 2010 Disaster Recovery and High Availability

Few IT professionals take the time to learn what needs to be known to do disaster recovery well. Most labor under the pretense that good , equals close to five-nines uptime. Most technical people do not see the value of planning for disasters until the unexpected has already happened, and the effects of a disaster involving a , farm-which today houses , information, line-of-business applications, sensitive information, extranets, and other highly important assets-can be staggering.

Pro SharePoint 2010 Disaster Recovery and High Availability

Pro SharePoint 2010 Administration

Pro SharePoint 2010 Administration

Pro SharePoint 2010 Administration is a practical guide to , 2010 for intermediate to advanced SharePoint administrators and power users, covering the out-of-the-box feature set and capabilities of Microsoft’s collaboration and , productivity platform.,

Starting with a detailed deployment and initial configuration walkthrough, the book covers all major feature areas, including document management, social computing, metadata management, and administration. You’ll also learn about planning for capacity, backup , and disaster recovery, business intelligence, monitoring, and more. Unlike other books, Pro SharePoint 2010 Administration covers all elements of the product, but has a specific emphasis on features new and enhanced in the 2010 release.

Pro SharePoint 2010 Administration

Microsoft SharePoint 2013 Disaster Recovery Guide

Microsoft SharePoint 2013 Disaster Recovery Guide

Where does it all go wrong with disaster recovery? Yes, why a disaster recovery plan fails the , and costs IT staff their jobs or a promotion? This book is an easytounderstand guide that explains how to get it right and why it often goes wrong.,

Given that Microsoft’s , platform has become a missioncritical application where business operations just cannot run without complete uptime of this technology, disaster recovery is one of the most important topics when it comes to SharePoint. Yet, support and an appropriate approach for this technology are still difficult to come by, and are often vulnerable to technical oversight and assumptions.

Microsoft SharePoint 2013 Disaster Recovery Guide