DNA Structure and Function

DNA Structure and Function

DNA Structure and Function, a timely and comprehensive resource, is intended for any student or scientist interested in DNA structure and its biological implications. The book provides a simple yet comprehensive introduction to nearly all aspects of DNA structure. It also explains current ideas on the biological significance of classic and alternative DNA conformations. Suitable for graduate courses on DNA structure and nucleic acids, the text is also excellent supplemental reading for courses in general biochemistry, molecular biology, and genetics.

DNA Structure and Function

An Introduction to Toxicology

An Introduction to Toxicology

This book provides a readable introduction to modern toxicology with a particular focus on the mechanisms underlying the induction of toxicity by foreign substances. Since bioactivation is central to many toxic syndromes, special interest is devoted to chemicals that undergo conversion to toxic metabolites that induce toxic effects as diverse as cancer, birth defects and organ injury. The molecular consequences accompanying damage to cellular DNA and proteins is explored together with the relevance of toxicological paradigms to human diseases caused by alcohol and tobacco. The discipline of toxicology has developed rapidly since the thalidomide disaster in the 1960s as scientists worldwide seek to understand the adverse health effects of human medicines, environmental pollutants, consumer chemicals and industrial reagents. An Introduction to Toxicology is intended to supplement the recommended reading list of undergraduate and graduate programs in toxicology and pharmacology as an enjoyable, accessible primer with illustrations that unpack the concepts being discussed in the text.

An Introduction to Toxicology

Multi-Step Enzyme Catalysis

Multi-Step Enzyme Catalysis

The first comprehensive coverage of this unique and interdisciplinary field provides a complete overview, covering such topics as chemoenzymatic synthesis, microbial production of DNA building blocks, asymmetric transformations by coupled enzymes and much more. By combining enzymatic and synthetic organic steps, the use of multi-enzyme complexes and other techniques opens the door to reactions hitherto unknown, making this monograph of great interest to biochemists, organic chemists, and chemists working with/on organometallics, as well as catalytic chemists, biotechnologists, and those working in the pharmaceutical and fine chemical industries.

Multi-Step Enzyme Catalysis

Straw Men

Straw Men

Convicted of a vicious attack that left a rookie policewoman near death and unable to remember her past, new DNA evidence frees the madman known as the Scarecrow from prison. Teresa Harnett must face the possibility that her flawed memory put the wrong man behind bars. But then the phone calls begin — and the crackly voice of the Scarecrow reawakens her terror. Only psychologist Jim Christensen can pull the truth from her shattered mind.

Straw Men

Homology Effects

Homology Effects

Homology Effects offers contributions from an international panel of researchers whose aim has been both to introduce newcomers to the field of homology effects, and to bring colleagues up to date. Topic coverage includes dosage compensation, X-inactivation, imprinting, paramutation, homology-dependent gene silencing, transvection, pairing-sensitive silencing, nuclear organization of chromosomes, DNA repair, quelling, RIP, RNAi and antisense biology, homology effects in ciliates, prion biology, and a discourse on the evolution of gene duplications.

Homology Effects

Bioanalytical Applications of Enzymes

Bioanalytical Applications of Enzymes

Details the latest advances in bioanalytical applications using enzymes–techniques that are becoming increasingly important in analysis, synthesis, manufacturing and medical diagnosis. Consists of seven articles which cover: enzyme labeled antibodies in bioassays, DNA restriction enzymes and RFLPs in medicine, enzyme-labeled probes for nucleic acid hybridization, unique methodologies of immobilized proteins in bioanalytical systems, dry reagent chemistry fundamentals, the theory and applications of enzyme electrode biosenors, and advances in enzymatically coupled field effect transistors.

Bioanalytical Applications of Enzymes

Nanopores for Bioanalytical Applications

Nanopores for Bioanalytical Applications

Bioanalytical applications in nanopores are an exciting field of research which have seen rapid development over the last ten plus years. This book focuses uniquely on this research area providing an insight from the world leading experts in the area. Based on the proceedings of the 1st International Conference on Nanopores for Bioanalytical Applications (Lanzarote, 2012), it will provide a snapshot of this exciting field for the nanopores community. It describes the latest experimental and fabrication protocols necessary to carry out nanopore-based experiments and covers a wide variety of topics. These include: biological pores, solid state pores, hybrid structures, fundamental aspects, work on the underlying (bio)physics and applications in biosensing and DNA sequencing. The multidisciplinary approach to this topic makes the book suitable for readers in both academia and industry.

Nanopores for Bioanalytical Applications

Single Cell Diagnostics

Single Cell Diagnostics

Single Cell Diagnostics: Methods and Protocols applies modern molecular diagnostic techniques to the analysis of single cells, small numbers of cells, or cell extracts. Emphasis is placed on non-invasive analysis of single cell metabolites and the direct analysis of RNA and DNA from single cells, with a focus on polymerase chain reaction and fluorescence in situ hybridization. The authors, all leading scientists in the field, provide current and innovative methods for extracting useful, accurate, and reliable data from single-cell samples. The stepwise, technically precise protocols presented in this volume thoroughly describe single-cell assays, from material collection and isolation of cells to data interpretation. Cell-types analyzed include embryonic blastomeres, fibroblasts, and lymphocytes. Among the techniques described are real-time quantitative PCR, isothermal whole genome amplification, comparative genomic hybridization, real-time genetic expression analysis, and the production of RNA and cDNA libraries. This handbook will be essential for researchers and clinicians, and practitioners providing care for couples seeking treatment for infertility or preimplantation genetic diagnosis. Book jacket.

Single Cell Diagnostics

Making Embedded Systems

Making Embedded Systems

Interested in developing embedded systems? Since they don’t tolerate inefficiency, these systems require a disciplined approach to programming. This easy-to-read guide helps you cultivate a host of good development practices, based on classic , , , and new patterns unique to embedded programming. Learn how to build system architecture for processors, not operating systems, and discover specific techniques for dealing with hardware difficulties and manufacturing requirements.,

Written by an expert who’s created embedded systems ranging from urban surveillance and DNA scanners to children’s toys, this book is ideal for intermediate and experienced programmers, no matter what platform you use.

Making Embedded Systems