Sodium Calcium Exchange:

Sodium Calcium Exchange:

This book reports the text of the lectures of the 6th International Conference on Sodium Calcium Exchange held in Lacco Ameno in the Island of Ischia in the Gulf of Naples, Italy, from October 1 to October 5, 2011. The present book uncovers the most striking new findings on NCX that emerged since the previous Conference on Sodium Calcium Exchange, such as the structural dissection of the molecular determinants of Ca2+ sensitivity of the exchanger, the epigenetic regulation of ncx1 gene, the molecular identification of the mitochondrial Sodium Calcium Exchanger, and the discovery of NCX in unexpected anatomical locations such as the female reproductive tract.The book is organized into 11 parts covering NCX structural aspects, genetic and epigenetic regulation, regulatory mechanisms, subcellular localization in mitochondria, involvement in neurodegenerative diseases and in immune regulation, and the role of the cardiovascular and endocrine systems, as well as diabetes in physiology and pathophysiology. Selected chapters of the book are also devoted to the interaction of NCKX and other ion channels and transporters with NCX, like ASICs, TRPM, and NHE.

Sodium Calcium Exchange:

Machina Carnis

Machina Carnis

Originally published in 1971, this is an account of the centuries of experiment and speculation that have led to our understanding of how muscles work. The book traces all the developments in the field since 1600 and devotes special attention to the breakthroughs made in the last century. It considers the nature of the muscle machine and its fuel, as well as the intricate regulation of energy supply under different conditions. It also examines the very varied kinds of muscle and the effects of some diseases on their structure and function. Finally it shows how the energy metabolism first elucidated for the mechanical work of muscle has been found to explain most of the other kinds of work done by cells, as in light production, secretion, ionic transport and electrical discharge. The biochemistry of muscle, carbohydrate metabolism and phosphorylations was the author’s chosen field of research for over forty years.

Machina Carnis

Spinal Injuries and Conditions in Young Athletes

Spinal Injuries and Conditions in Young Athletes

Spinal Injuries and Conditions in Young Athletes provides a comprehensive, in-depth review of the mechanisms and management of back injuries and problems occurring in this ever-growing and active population. Led by Dr. Lyle Micheli and his co-editors, an award-winning group of orthopedists discusses and explores common adolescent spine injuries and procedures, in addition to breakthroughs in gene therapy, tissue engineering, and complex operations. As spine surgery is among the most complex and challenging procedures performed in orthopedics, special considerations and procedures are required in pediatric populations. Since many corrective surgeries run the risk of arthritis later in life, particular efforts must be made in young populations to prevent future injury in a child’s adolescence and young adulthood while maximizing return-to-play potential. Chapters cover acute spinal injuries, concussions, overuse injuries, spinal malformations, tumors, infections and inflammatory diseases across the range of athletics, including swimming and combat sports. Spinal Injuries and Conditions in Young Athletes provides an immeasurable guide for back surgery in pediatric populations and will be a go-to resource for practitioners and residents in pediatric orthopedics and sports medicine.

Spinal Injuries and Conditions in Young Athletes

An Introduction to Toxicology

An Introduction to Toxicology

This book provides a readable introduction to modern toxicology with a particular focus on the mechanisms underlying the induction of toxicity by foreign substances. Since bioactivation is central to many toxic syndromes, special interest is devoted to chemicals that undergo conversion to toxic metabolites that induce toxic effects as diverse as cancer, birth defects and organ injury. The molecular consequences accompanying damage to cellular DNA and proteins is explored together with the relevance of toxicological paradigms to human diseases caused by alcohol and tobacco. The discipline of toxicology has developed rapidly since the thalidomide disaster in the 1960s as scientists worldwide seek to understand the adverse health effects of human medicines, environmental pollutants, consumer chemicals and industrial reagents. An Introduction to Toxicology is intended to supplement the recommended reading list of undergraduate and graduate programs in toxicology and pharmacology as an enjoyable, accessible primer with illustrations that unpack the concepts being discussed in the text.

An Introduction to Toxicology

Microperimetry and Multimodal Retinal Imaging

Microperimetry and Multimodal Retinal Imaging

Microperimetry allows precise functional examination of the retina and optic nerve and is especially valuable for evaluation of the macular area. This fully up-to-date textbook on microperimetry, written by leading experts in the field, will also serve as an atlas and diagnostic reference. It is designed for use by both ophthalmologists and optometrists in daily clinical practice and clinical research, and the contents thus range from basic technical information to the most advanced clinical applications. Past and current microperimetry techniques are reviewed, and the role of microperimetry in the context of multimodal imaging scenario is explained. The full range of clinical applications is then discussed, including age-related macular degeneration, diabetes, myopia, retinal dystrophies, disorders of the vitreoretinal interface, inflammatory chorioretinal diseases, toxic retinopathies, glaucoma, and low vision.

Microperimetry and Multimodal Retinal Imaging

Morphological Aspects of Inner Ear Disease

Morphological Aspects of Inner Ear Disease

Sudden deafness and Meniere’s Disease are common inner ear diseases diagnosed around the globe. However, their causes and etiologies are still unknown due to several reasons. One key factor is simply that the inner ear is small and located in the hard temporal bo the resolution of CT and MRI images is insufficient in analyzing the pathophysiology of the inner ears under such circumstances. As these diseases are not fatal, the opportunities of obtaining temporal bones for histopathological examinations are rather rare. This book tries to improve the situation by approaching the inner ear diseases, especially the perilymphatic fistula, from multifaceted perspectives. It provides morphological information of the inner ear accompanying the chapters, i.e., explanations of inner ear fluids and blood vessels that help readers get familiar with complicated inner ear structures. It contains chapters describing specific diseases such as sudden deafness, Meniere’s Disease and viral diseases to understand them in depth. Animal models of the diseases described in the book also help readers better understand inner ear diseases that normally remain obscure. Patients with intractable vertigo of inner-ear origin need surgical treatment and an application of a laser to the vestibular labyrinth is another topic of interest to readers, for lasers allow a precise treatment. Various examples of experiments are also provided in the book to give readers an idea of surgical applications. This book is recommended as a professional reference text and monograph for all doctors and trainees in the otolaryngology field focusing on the ear, nose and throat.

Morphological Aspects of Inner Ear Disease

Hair and Scalp Diseases

Hair and Scalp Diseases

Hair and Scalp Diseases: Medical, Surgical, and Cosmetic Treatments is a succinct and comprehensive guide examining the treatment of scalp and hair disorders, with a special concentration on ethnicity, hair type, and morphology of hair. Treatments that go beyond accepted US and international guidelines are incorporated, as the authors examine the use of off-label medications in case-sensitive scenarios. Packed with photographs of the scalp and hair that document the pathology, clinical cases, and treatment solutions, Hair and Scalp Diseases: Medical, Surgical, and Cosmetic Treatments

Hair and Scalp Diseases

Progress in Temperate Fruit Breeding

Progress in Temperate Fruit Breeding

This book contains the papers and posters presented at the Eucarpia Fruit Breeding Section Meeting held at Wadenswil/Einsiedeln, Switzerland from August 30 to September 3, 1993. It gives an overview of the latest trends in temperate fruit breeding in Europe and overseas. Three subjects were considered in special workshops: durability of scab resistance in apple, biotechnology and molecular markers. One important aim of modern fruit breeding is stable resistance against pests and diseases. Molecular markers might help to identify the genetic basis of important characteristics related to disease and pest resistance and components of yield and quality. Gene transfer has been successfully applied in several fruit species. However, public opinion in many countries does not favour this new technology and its products. Despite these new approaches, traditional breeding methods still predominate; many aspects of traditional breeding are considered in this book. Genetic resources and their exploitation are discussed in a special chapter. Aspects of breeding minor crops such as walnut, almond, hippophae, cornel are also considered. Progress in Temperate Fruit Breeding should interest fruit breeders, pomologists, lecturers, students and growers.

Progress in Temperate Fruit Breeding

Inborn Metabolic Diseases - Fifth Edition

Inborn Metabolic Diseases - Fifth Edition

This henceforth classical textbook has become indispensable for those in the front line dealing with metabolic disorders. As with previous editions the book is aimed at all those involved with this specialty including pediatricians, biochemists, dieticians, neurologists, internists, geneticists, psychologists, nurses, and social workers. This 4th edition has been thoroughly updated and revised and John Walter has joined the three other editors. One new chapter on Neonatal screening by tandem MS/MS has been added and several new groups of disorders have been included; for example defects involving the pentose phosphate pathway (polyols metabolism) and disorders of glucose transport. The first chapter presents the clinical approach to inherited metabolic disease using many algorithms and tables and has been entirely revised and extended to include adult metabolic medicine. It now incorporates many new findings particularly in neuroradiology and neurophysiology and emphasises those disorders for which treatment is available. This accessible and practical book can be used either by going directly to the relevant chapter when the diagnosis is already suspected or by referring to Chapter 1 if it is unknown. Despite the numerous updates the book has been maintained at a reasonable size and is published as a single volume of approximately 550 pages divided into 43 Chapters.

Inborn Metabolic Diseases - Fifth Edition

THC and Tropacocaine

THC and Tropacocaine

THC is a new miracle medication, used to treat sleep disorders allergies, inflammatory diseases, auto immune disorders, migraines, addictions, post traumatic stress disorder, anorexia, etc.

THC and Tropacocaine

Neurobiology of Acupuncture, Volume 111

Neurobiology of Acupuncture, Volume 111

This book summarises the recent development in acupuncture research and in particular, the neurobiology of acupuncture. It provides a focus but a diverse range of subjects covering many body systems. The first a few chapters discuss the basic principles of acupuncture, then its modulatory effects on nervous system such as induction of neurotrophin and neurogenesis in the brain. Late chapters explore the clinical effects and potential mechanisms of acupuncture on different conditions ranging from neurological diseases such as Parkinsons, Alzheimers, and stroke, to psychiatric illnesses, insomnia, hypertension, gastrointestinal diseases and drug addiction. We believe this will promote the understanding acupuncture treatment and enhance acupuncture research in the future.

Neurobiology of Acupuncture, Volume 111

Touch of Power

Touch of Power

Laying hands upon the injured and dying, Avry of Kazan absorbs their wounds and diseases into herself. But rather than being honored for her skills, she is hunted. Healers like Avry are accused of spreading the plague that has decimated the Fifteen Realms, leaving the survivors in a state of chaos.

Touch of Power

The Therapeutic Use of Ayahuasca

The Therapeutic Use of Ayahuasca

This book presents a series of perspectives on the therapeutic potential of the ritual and clinical use of the Amazonian hallucinogenic brew ayahuasca in the treatment and management of various diseases and ailments, especially its role in psychological well-being and substance dependence. Biomedical and anthropological data on the use of ayahuasca for treating depression, PTSD, and substance dependence in different settings, such as indigenous contexts, neo-shamanic rituals, contemporary therapeutic circles, and in ayahuasca religions, in both South and North America, are presented and critiqued. Though multiple anecdotal reports on the therapeutic use of ayahuasca exist, there has been no systematic and dense reflection on the topic thus far. The book brings the therapeutic use of ayahuasca to a new level of public examination and academic debate. The texts in this volume stimulate discussion on methodological, ethical, and political aspects of research and will enhance the development of this emergent field of studies.

The Therapeutic Use of Ayahuasca

An Osteopathic Approach to Children

An Osteopathic Approach to Children

This evidence-based, fully referenced text offers a wealth of information on the use of osteopathic techniques for pediatric disorders — from newborns to adolescents. It discusses normal development, physiology, and anatomy of the systems, and it explores conditions and diseases of childhood as well as the rationale for osteopathic treatment. Practical and comprehensive, it offers an osteopathic approach to understanding the development of the cranium; the interrelatedness of posture, movement, and cognition; and the process of labor and birth.

An Osteopathic Approach to Children

Toxin

Toxin

What do the following have in common: the promise of Botox as the key to everlasting youthful looks; E. coli O157 hamburger disease; a mysterious illness which killed 35 heroin users in 2000; and the assassination by poisoned umbrella-tip of a Bulgarian dissident in the 1970s? The answer is that all of these are caused by toxins, the powerful biological poisons released by bacteria and some plants.In Toxin, Alistair Lax reveals the panoply of ways in which bacterial toxins overcome the defences of our cells. He explains how they work, how they are so successful in causing major diseases, the terrible human impact they have had, and how apparently ‘new’ diseases arise from them. He also discusses how we can combat toxins, and how we can harness their actions for beneficial purposes. Enlivened by the very human story of the persistence, rivalries, and insights from which modernmicrobiology grew, Toxin is the first widely accessible account of this exciting and important topic.

Toxin

Hair Loss Disorders in Domestic Animals

Hair Loss Disorders in Domestic Animals

Hair Loss Disorders in Domestic Animals is an in-depth reference on the pathomechanisms and clinical approaches of all skin diseases in domestic animals that have hair loss as the predominant clinical feature. It presents both basic and clinically-relevant knowledge on alopecic disease in animals. This text is a one-of-a-kind resource providing cutting-edge coverage of the physiology and pathology of hair follicles. Disease-specific chapters include: a detailed description of the disease entity, etiology, pathogenesis, clinical and histopathological diagnosis and treatment modalities.

Hair Loss Disorders in Domestic Animals

Allergy and Allergic Diseases, Volume 1

Allergy and Allergic Diseases, Volume 1

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Allergy and Allergic Diseases, Volume 1

Encyclopedia of Diseases and Disorders

Encyclopedia of Diseases and Disorders

Provides instructive articles for more than 200 infectious and non-infectious diseases and mental disorders, augmenting each report with information about risk factors, symptoms and prevention methods, in a volume complemented by a glossary of terms and resources for further study.

Encyclopedia of Diseases and Disorders