Sodium Calcium Exchange:

Sodium Calcium Exchange:

This book reports the text of the lectures of the 6th International Conference on Sodium Calcium Exchange held in Lacco Ameno in the Island of Ischia in the Gulf of Naples, Italy, from October 1 to October 5, 2011. The present book uncovers the most striking new findings on NCX that emerged since the previous Conference on Sodium Calcium Exchange, such as the structural dissection of the molecular determinants of Ca2+ sensitivity of the exchanger, the epigenetic regulation of ncx1 gene, the molecular identification of the mitochondrial Sodium Calcium Exchanger, and the discovery of NCX in unexpected anatomical locations such as the female reproductive tract.The book is organized into 11 parts covering NCX structural aspects, genetic and epigenetic regulation, regulatory mechanisms, subcellular localization in mitochondria, involvement in neurodegenerative diseases and in immune regulation, and the role of the cardiovascular and endocrine systems, as well as diabetes in physiology and pathophysiology. Selected chapters of the book are also devoted to the interaction of NCKX and other ion channels and transporters with NCX, like ASICs, TRPM, and NHE.

Sodium Calcium Exchange:

Forensic Medicine

Forensic Medicine

This book, which combines the features of an atlas and a textbook, presents findings in forensic histology, immunohistochemistry, and cytology based on microscopic investigations using different stainings and different antibodies. The principal aim is to provide practitioners with detailed information and guidance on how microscopy can help to clarify the cause of sudden and unexpected death. Many of the topics will be of interest not only to forensic pathologists but also to general pathologists, whether practitioners or researchers. Examples include the pathology of drug abuse, wound age determination, adverse drug reactions, histopathology of the sudden infant death syndrome, and age determination of myocardial infarction. Both typical and unusual findings are demonstrated with the aid of numerous high-quality color illustrations, and other key literature in forensic histology and immunohistochemistry is highlighted for each topic.

Forensic Medicine

Cardiac CT and MR for Adult Congenital Heart Disease

Cardiac CT and MR for Adult Congenital Heart Disease

This is the first major textbook to address both computed tomography (CT) and magnetic resonance (MR) cardiac imaging of adults for the diagnosis and treatment of congenital heart disease (CHD). Since the introduction of faster CT scanners, there has been tremendous advancement in the diagnosis of CHD in adults. This is mostly due to the higher spatial resolution of CT compared to MR, which enables radiologists to create more detailed visualizations of cardiac anatomic structures, leading to the discovery of anomalous pathologies often missed by conventional MR imaging. This book is unique in highlighting the advantages of both CT and MR for the diagnosis of CHD in adults, focusing on the complementary collaboration between the two modalities that is possible. Chapters include discussions of case examples, clinical data, MR and CT image findings, and correlative cadaveric pictures. The chapters focus not only on the diagnosis of the primary problem, but also give readers information on visual clues to look for that often reveal associated pathologies. This book appeals primarily to diagnostic and interventional radiologists, as well as cardiologists and interventional cardiologists.

Cardiac CT and MR for Adult Congenital Heart Disease

Encyclopedia of Adolescence

Encyclopedia of Adolescence

The period of adolescence involves growth, adaptation, and dramatic reorganization in almost every aspect of social and psychological development. The Encyclopedia of Adolescence offers an exhaustive and comprehensive review of current theory and research findings pertaining to this critical decade of life. Leading scientists offer accessible and easily readable reviews of biological, social, educational, occupational, and cultural factors that shape adolescent development. Issues in normative development, individual differences, and psychopathology/maladjustment are reviewed. Over 130 chapters are included, each covering a specific aspect or issue of adolescence. The chapters trace differences in the course of adolescence in different nations and among youth with different backgrounds.

Encyclopedia of Adolescence

Flavor Chemistry

Flavor Chemistry

Celebrating the founding of the Flavor Subdivision of the Agriculture and Food Chemistry Division of the American Chemical Society, this book provides an overview of progress made during the past 30-40 years in various aspects of flavor chemistry as seen by internationally renowned scientists in the forefront of their respective fields. In addition, it presents up-to-date findings in the areas of flavor chemistry, analytical methods, thermally produced flavors and precursors, enzymatically produced flavors and precursors, and sensory methods and results.

Flavor Chemistry

How Very Effective Primary Schools Work

How Very Effective Primary Schools Work

‘Chris James, Michael Connolly, Gerald Dunning and Tony Elliott have produced a comprehensive analysis of the very effective primary school. Although the research for the book draws on the authors experiences in Welsh Primary Schools, the range of literature cited and the analytical frameworks employed ensure that their findings have a much broader relevance. They define a very effective school as one that provides high levels of attainment and rich educational experiences despite being located in extremely challenging circumstances. A key insight of the book is that although these schools are consequently extraordinary their practice was in many ways quite ordinary. This is because these schools worked in much the same way as the very best of schools have always done. In many ways, this as the authors note, is an optimistic message that all children deserve to be educated in such very effective schools. The virtue of How Very Effective Primary Schools Work is that it makes clear those characteristics and strategies that can help every school to become great’ – David Hopkins, HSBC iNet Chair of International Leadership, and formerly Chief Adviser on School Standards to the Secretary of State 2002-2005

How Very Effective Primary Schools Work

Rethinking History, Reframing Identity

Rethinking History, Reframing Identity

This book contributes to the theoretical and methodological discussion about how the diverging experiences of generations and their historical memories play a role in the process of national identity formation. Drawing from narratives gathered within the Ukrainian minority in northern Poland and centered on the collective trauma of Action Vistula, where in 1947 about 140,000 Ukrainians were resettled from south-eastern Poland and relocated to the north-western areas, this study shows that three generations vary considerably with regard to their understandings of home, integration, history and religion. Thus, generational differences are an essential element in the analysis and understanding of social and political change. The findings of this study provide a contribution to debates about the process based nature of national identity, the role of trauma in creating generational consciousness and how generations should be conceptualized.

Rethinking History, Reframing Identity

Langes Handbook of Chemistry - 15th Edition

Langes Handbook of Chemistry - 15th Edition

A standard reference for chemists for 70 years, this new Sixteenth Edition features an enormous compilation of facts, data, tabular material, and experimental findings in every area of chemistry.Included in this massive compendium are listings of the properties of approximately 4,400 organic and 1,400 inorganic compounds. This Sixteenth Edition offers 40% new or extensively revised content and starting with this edition, the author includes equations that allow users to calculate important values such as temperature and pressure.

Langes Handbook of Chemistry - 15th Edition

Armed Attack and Article 51 of the UN Charter

Armed Attack and Article 51 of the UN Charter

This book examines to what extent the right of self-defence, as laid down in Article 51 of the Charter of the United Nations, permits States to launch military operations against other States. In particular, it focuses on the occurrence of an ‘armed attack’ – the crucial trigger for the activation of this right. In light of the developments since 9/11, the author analyses relevant physical and verbal customary practice, ranging from the 1974 Definition of Aggression to recent incidents such as the 2001 US intervention in Afghanistan and the 2006 Israeli intervention in Lebanon. The notion of ‘armed attack’ is examined from a threefold perspective. What acts can be regarded as an ‘armed attack’? When can an ‘armed attack’ be considered to take place? And from whom must an ‘armed attack’ emanate? By way of conclusion, the different findings are brought together in a draft ‘Definition of Armed Attack’.

Armed Attack and Article 51 of the UN Charter

Hitlers Shadow

Hitlers Shadow

The report is based on findings from newly-declassified decades-old Army and CIA records released under the Nazi War Crimes Disclosure Act of 1998 (the Act), these records were processed and reviewed by the National Archives-led Nazi War Crimes and Japanese Imperial Government Records Interagency Working Group (IWG), and written by IWG historians Richard Breitman and Norman J.W. Goda. The report highlights materials opened under the Act, in addition to records that were previously opened but had not been mined by historians and researchers, including records from the Office of Strategic Services (a CIA predecessor), dossiers of the Army Staff’s Intelligence Records of the Investigative Records Repository (IRR), State Department records, and files of the Navy Judge Advocate General.

Hitlers Shadow

Glaucoma Surgery

Glaucoma Surgery

Renowned experts present the latest knowledge in … In this volume of Developments in Ophthalmology, a panel of renowned glaucoma surgeons reports its findings and the updated evidence-based literature data on indications, outcomes, pearls and pitfalls of techniques in which they all have an undisputable ‘hands-on’ everyday experience. The publication begins with chapters on conventional procedures, i.e. trabeculectomy (still the gold standard), deep sclerectomy, and glaucoma drainage device implantation explicitly focusing on postoperative management. The role of the ocular surface in glaucoma surgery and the issue of wound healing and its modulation through antimetabolites are further discussed. In the second part, the attention shifts to new techniques which still have a marginal role, but are promising for particular indications. In the last part, the greatest challenges of glaucoma surgery such as the surgical approach to angle closure, concomitant glaucoma and cataract as well as pediatric glaucoma are discussed in detail. Finally, the last chapter is dedicated to cyclodestructive techniques. This volume is recommended to glaucoma surgeons and glaucoma specialists seeking information on the best therapy for their patients, but also to general ophthalmologists who refer their patients for surgery or follow them up afterwards.

Glaucoma Surgery

Teaching Number Sense

Teaching Number Sense

* What is number sense? * How does children’s number sense develop? * What are the most effective teaching methods and resources? * How can research findings inform classroom practice? The fully revised second edition of the best-selling ‘Teaching Number Sense’ is the book to help you answer these questions, and more. This new edition boasts a new chapter on ‘Numbers in Context’ as well as a wealth of material on all the latest trends and innovations in mathematics teaching to support children’s learning. It is a specialist text that uses a balance of theory and practice to help teachers deal with the problems and issues they will encounter in mathematics teaching, including examples for use specifically in the classroom. This book will prove essential reading for trainee and established mathematics teachers alike.

Teaching Number Sense

Inborn Metabolic Diseases - Fifth Edition

Inborn Metabolic Diseases - Fifth Edition

This henceforth classical textbook has become indispensable for those in the front line dealing with metabolic disorders. As with previous editions the book is aimed at all those involved with this specialty including pediatricians, biochemists, dieticians, neurologists, internists, geneticists, psychologists, nurses, and social workers. This 4th edition has been thoroughly updated and revised and John Walter has joined the three other editors. One new chapter on Neonatal screening by tandem MS/MS has been added and several new groups of disorders have been included; for example defects involving the pentose phosphate pathway (polyols metabolism) and disorders of glucose transport. The first chapter presents the clinical approach to inherited metabolic disease using many algorithms and tables and has been entirely revised and extended to include adult metabolic medicine. It now incorporates many new findings particularly in neuroradiology and neurophysiology and emphasises those disorders for which treatment is available. This accessible and practical book can be used either by going directly to the relevant chapter when the diagnosis is already suspected or by referring to Chapter 1 if it is unknown. Despite the numerous updates the book has been maintained at a reasonable size and is published as a single volume of approximately 550 pages divided into 43 Chapters.

Inborn Metabolic Diseases - Fifth Edition

Openness, Economic Growth and Regional Disparities

Openness, Economic Growth and Regional Disparities

Substantial disparities across different Chinese regions are one of the most prominent features in Chinas development process. This book investigates the mechanisms through which openness affects regional economic growth and interregional disparities in China. Based on the latest data and employing a variety of panel data regression techniques, it provides readers with new findings that shed light on the effects of openness on Chinas regional economic growth and the evolution of the countrys interregional disparities.

Openness, Economic Growth and Regional Disparities

Cannabis And Cognitive Functioning

Cannabis And Cognitive Functioning

Cannabis is the most widely used illicit substance in the world, but the question of whether its long-term use can result in lasting and irreparable cognitive impairment remains controversial. This timely and well-argued volume provides an extensive and comprehensive critical review of the literature relevant to cannabis and cognitive functioning, examining the evidence in the light of important recent findings in the pharmacology and neuropsychology of cannabis. Original studies conducted by the author are presented, utilizing one of the most modern and sensitive tools available to assess cognitive functioning – event-related potentials or ERPs. Her conclusion, that long-term cannabis use may produce irreversible impairment in memory, attention and the organization and integration of complex functions, will be of compelling interest to a wide range of clinicians, researchers and policy makers.

Cannabis And Cognitive Functioning

Language Lateralization and Psychosis

Language Lateralization and Psychosis

In 1861 Paul Broca discovered that, in most individuals, the left hemisphere of the brain is dominant for language. Taking language as an example, the first part of this book explains the normal development of bodily asymmetry and lateralization, its association with hand preference, genetic aspects, geographical differences and the influence of gender. The coverage then moves on to review the association between language lateralization and psychosis, describing findings in patients with schizophrenia to suggest the dominant hemisphere may fail to completely inhibit the language areas in the non-dominant half. The language allowed to ‘release’ from the right hemisphere can lead to psychotic symptoms including auditory verbal hallucinations and formal thought disorder. This book should be read by psychiatrists, neurologists and neuroscientists working in the field of psychosis and other brain scientists interested in laterality.

Language Lateralization and Psychosis

Applied Plant Cell Biology

Applied Plant Cell Biology

The aim of this volume is to merge classical concepts of plant cell biology with the recent findings of molecular studies and real-world applications in a form attractive not only to specialists in the realm of fundamental research, but also to breeders and plant producers. Four sections deal with the control of development, the control of stress tolerance, the control of metabolic activity, and novel additions to the toolbox of modern plant cell biology in an exemplary and comprehensive manner and are targeted at a broad professional community. It serves as a clear example that a sustainable solution to the problems of food security must be firmly rooted in modern, continuously self re-evaluating cell-biological research.

Applied Plant Cell Biology

School Discourse

School Discourse

Writing development has been a key area of research in applied linguistics for some time but most work has focused on children’s writing at particular ages, for example, at the early primary, late primary or secondary stage.? Christie and Derewianka draw on extensive research in both primary and secondary years to trace the developmental trajectory from age 5 or 6 through to 18.? Using a systemic functional grammar, they outline developmental changes in writing in three major areas of the school curriculum – English, history, and science – as children move from early childhood to late childhood and on to adolescence and adulthood.? The book considers the nature of the curriculum at various stages, discussing the interplay of curriculum goals, pedagogy and developmental changes as children grow older.? It also explores how emergent control of the different subjects requires control of various subject specific literacies and considers the pedagogical implications of their findings.? It will be of interest to anyone involved in the writing performance of children in schools, particularly applied and educational linguists.

School Discourse

Plant Biochemistry, Fourth Edition

Plant Biochemistry, Fourth Edition

This fully revised translation of the world-renowned German edition covers the complete and modern knowledge of plant biochemistry. The book presents the topic in a concise and simplified manner so that students can digest the message and gain a basic knowledge of the entire field of plant biochemistry, from photosynthesis (the synthesis of natural plant products) to all kinds of genetic engineering with its many commercial applications. Topics include cell structure and function, lipid and polysaccharide metabolism, nitrogen fixation, phloem transport, synthesis and function of isoprenoids, phenylpropanoids and other secondary metabolites, plant growth regulation and development. Heldt provides a comprehensive description of photosynthesis, primary and secondary metabolism, the function of phytohormones and molecular engineering. The text covers research findings until the end of 2003 and identifies areas of future research. There are extensive references to the most recent scientific literature.

Plant Biochemistry, Fourth Edition

Psycho-Physical Dualism Today

Psycho-Physical Dualism Today

Until quite recently, mind-body dualism has been regarded with deep suspicion by both philosophers and scientists. This has largely been due to the widespread identification of dualism in general with one particular version of it: the interactionist substance dualism of RZnZ Descartes. This traditional form of dualism has, ever since its first formulation in the seventeenth century, attracted numerous philosophical objections and is now almost universally rejected in scientific circles as empirically inadequate. During the last few years, however, renewed attention has begun to be paid to the dualistic point of view, as a result of increasing discontent with the prevailing materialism and reductionism of contemporary scientific and philosophical thought. Awareness has grown that dualism need not be restricted to its traditional form and that other varieties of dualism are not subject to the difficulties commonly raised against Descartes’ own version of it. Interest in these alternative versions of dualism is growing fast today, because it seems that they are capable of capturing deep-seated philosophical intuitions, while also being fully consistent with the methodological assumptions and empirical findings of modern scientific work on the human mind and brain. The object of this book is to provide philosophers, scientists, their students, and the wider general public with an up-to-date overview of current developments in dualistic conceptions of the mind in contemporary philosophy and science.

Psycho-Physical Dualism Today